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TranscriptomicsFunctional profiling in yeast with the benzene metabolites hydroquinone, catechol and 1,2,4-benzenetriol
Benzene is a ubiquitous environmental contaminant and is widely used in industry. Exposure to benzene causes a number of serious health problems, including blood disorders and leukemia. Benzene undergoes complex metabolism in humans, making mechanistic determination of benzene toxicity difficult. We...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-13 | E-GEOD-45116 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in Daphnia magna, Part III: Uncovering Biomarkers for Metal and ORC exposures
To determine toxicant specific effects of Ordnance Related Compound (ORC) exposure we performed microarray hybridizations with RNA isolated from Daphnia magna following different ORC exposures at the 1/10 LC50. The gene expression profiles revealed toxicant specific gene expression profiles allowed...
ORGANISM(S): Daphnia magna 
2010-05-18 | E-GEOD-13169 | biostudies-arrayexpress
TranscriptomicsFunctional profiling in yeast with zinc-limitation
Zinc is an essential nutrient because it is a required cofactor for many enzymes and transcription factors. To discover genes and processes in yeast that are required for growth when zinc is limiting, we used genome-wide functional profiling. As a result, we identified over 400 different genes requi...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-16 | E-GEOD-37254 | biostudies-arrayexpress
TranscriptomicsUsing Gene Expression to Assess the Status of Fish from Anthropogenically Influenced Estuarine Wetlands
The diverse mixture of contaminants frequently present in estuarine wetlands complicates their assessment by routine chemical or biological analyses. We investigated the use of gene expression to assess contaminant exposure and the condition of southern California (USA) estuarine fish. Liver gene...
ORGANISM(S): Gillichthys mirabilis 
2011-04-19 | E-GEOD-28695 | biostudies-arrayexpress
TranscriptomicsThe Molecular Toxicity Identification Evaluation (mTIE) Approach Predicts Chemical Exposure in Daphnia magna
Daphnia magna is a bio-indicator organism accepted by several international water quality regulatory agencies. Current approaches for assessment of water quality rely on acute and chronic toxicity that provide no insight into the cause of toxicity. Recently, molecular approaches, such as genome wid...
ORGANISM(S): Daphnia magna 
2013-01-17 | E-GEOD-43564 | biostudies-arrayexpress
TranscriptomicsEcotoxicogenomics: interlaboratory comparability of microarray data [LabA_WB]
Additional toxicity testing and regulation are needed as the number of compounds chronically released into aquatic coastal environments increases. Decision makers require comprehensive and efficient screening tools to detect adverse biological effects and to identify their cause. Transcriptomic anal...
ORGANISM(S): Eohaustorius estuarius 
2015-01-26 | E-GEOD-64203 | biostudies-arrayexpress
TranscriptomicsEcotoxicogenomics: interlaboratory comparability of microarray data [LabB_WB]
Additional toxicity testing and regulation are needed as the number of compounds chronically released into aquatic coastal environments increases. Decision makers require comprehensive and efficient screening tools to detect adverse biological effects and to identify their cause. Transcriptomic anal...
ORGANISM(S): Eohaustorius estuarius 
2015-01-26 | E-GEOD-64205 | biostudies-arrayexpress
TranscriptomicsEcotoxicogenomics: interlaboratory comparability of microarray data [LabA_Ex]
Additional toxicity testing and regulation are needed as the number of compounds chronically released into aquatic coastal environments increases. Decision makers require comprehensive and efficient screening tools to detect adverse biological effects and to identify their cause. Transcriptomic anal...
ORGANISM(S): Eohaustorius estuarius 
2015-01-26 | E-GEOD-64202 | biostudies-arrayexpress
TranscriptomicsEcotoxicogenomics: interlaboratory comparability of microarray data [LabB_Ex]
Additional toxicity testing and regulation are needed as the number of compounds chronically released into aquatic coastal environments increases. Decision makers require comprehensive and efficient screening tools to detect adverse biological effects and to identify their cause. Transcriptomic anal...
ORGANISM(S): Eohaustorius estuarius 
2015-01-26 | E-GEOD-64204 | biostudies-arrayexpress
TranscriptomicsEcotoxicogenomics: interlaboratory comparability of microarray data [LabD_WB]
Additional toxicity testing and regulation are needed as the number of compounds chronically released into aquatic coastal environments increases. Decision makers require comprehensive and efficient screening tools to detect adverse biological effects and to identify their cause. Transcriptomic anal...
ORGANISM(S): Eohaustorius estuarius 
2015-01-26 | E-GEOD-64208 | biostudies-arrayexpress
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