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TranscriptomicsScreening for copy-number alterations and LOH in CLL - a comparative study of four microarray platforms
Screening for gene copy-number alterations (CNAs) has improved by applying genome-wide microarrays, where SNP arrays also allow analysis of loss of heterozygozity (LOH). We here analyzed 10 chronic lymphocytic leukemia (CLL) samples using four different high-resolution platforms: BAC arrays (32K), o...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-13557 | biostudies-arrayexpress
UnknownDissecting loss of heterozygosity (LOH) in neurofibromatosis type 1-associated neurofibromas: Importance of copy neutral LOH.
Not available
S-EPMC3151547 | biostudies-literature
TranscriptomicsSNP arrays in matched diagnosis/remission samples of normal karyotype-acute myeloid leukemia
We analysed, by last-generation high-resolution SNP arrays, Normal Karyotype (NK)-AML patients at diagnosis (Dx) and remission (R) phases, in order to determine the number of tumor-associated copy number abnormalities (CNAs) and copy neutral-loss of heterozygosity (CN-LOH) regions per patient and to...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21780 | biostudies-arrayexpress
UnknownIncorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine-purine inversion site of an RNA duplex.
Not available
S-EPMC5100590 | biostudies-literature
UnknownTwo distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus.
Not available
S-EPMC8558845 | biostudies-literature
TranscriptomicsProfiles of genomic instability in high-grade serous ovarian cancer (HGSC) predict treatment outcome
Profiling of loss of heterozygosity (LOH) in HGSC, subcrouping HGSC by LOH-based clustering and comparing to the LOH profiles of triple-negative breast cancer [previously submitted; GSE19594]. Study for the correlation of LOH burdern and LOH-based subgroups to clinical response to platinum-based ch...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEOD-39130 | biostudies-arrayexpress
TranscriptomicsCNV and LOH analysis of patient sample PN11-0204
We saw a patient who presented with respiratory distress from birth due to interstitial lung disease. Before the age of three months a diagnosis of nephrotic syndrome was made. Lung biopsy revealed pulmonary interstitial glycogenosis. Despite extensive investigations, no known genetic or infectious ...
ORGANISM(S): Homo sapiens 
2012-08-28 | E-GEOD-40405 | biostudies-arrayexpress
UnknownInvestigation of Cervical Tumor Biopsies for Chromosomal Loss of Heterozygosity (LOH) and Microsatellite Instability (MSI) at the HLA II Locus in HIV-1/HPV Co-infected Women.
Not available
S-EPMC6803484 | biostudies-literature
TranscriptomicsProstatic Stromal Cell Gene Expression
We generated prostatic stromal microarray expression data for functional validation of our LOH/AI hot-/cold-spots in stroma. Stromal cells from normal peripheral zone tissue and from tumors are grown in culture, and were analyed on gene expression platform. Stromal cells cultured from normal periphe...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-34312 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP 6.0 array data for chordoma samples
Chordomas are rare, low to intermediate grade malignant bone tumors of the axial skeleton, believed to originate from the notochord. Treatment options are limited and mainly restricted to surgical excision, as chordomas have been proven to be largely resistant to conventional ionizing radiation and ...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-25720 | biostudies-arrayexpress
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