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TranscriptomicsAllele-specific chromosome conformations induced by a transgene- and locus-dependent imprinting
A reporter transgene displayed parental imprinting in mouse embryos when positioned into the Itga6 gene. The strong lacZ pattern of expression scored in embryos inheriting the transgene from a male was not present when transmitted from a female. The transgene exhibited maternal allele-specific DNA ...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-48148 | biostudies-arrayexpress
TranscriptomicsConvergent evolution of complex regulatory landscapes and pleiotropy at Hox loci
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-21 | E-GEOD-62269 | biostudies-arrayexpress
TranscriptomicsConvergent evolution of complex regulatory landscapes and pleiotropy at Hox loci (4C-seq)
Hox genes are required during the morphogenesis of both vertebrate digits and external genitals.We investigated whether transcription in such distinct contexts involves a shared enhancer-containing landscape. We show that the same regulatory topology is used, yet with some tissue-specific enhancer-p...
ORGANISM(S): Mus musculus 
2014-11-21 | E-GEOD-62265 | biostudies-arrayexpress
TranscriptomicsConvergent evolution of complex regulatory landscapes and pleiotropy at Hox loci (tiling)
Hox genes are required during the morphogenesis of both vertebrate digits and external genitals.We investigated whether transcription in such distinct contexts involves a shared enhancer-containing landscape. We show that the same regulatory topology is used, yet with some tissue-specific enhancer-p...
ORGANISM(S): Mus musculus 
2014-11-21 | E-GEOD-62073 | biostudies-arrayexpress
TranscriptomicsConvergent evolution of complex regulatory landscapes and pleiotropy at Hox loci (RNA-seq)
Hox genes are required during the morphogenesis of both vertebrate digits and external genitals.We investigated whether transcription in such distinct contexts involves a shared enhancer-containing landscape. We show that the same regulatory topology is used, yet with some tissue-specific enhancer-p...
ORGANISM(S): Mus musculus 
2014-11-21 | E-GEOD-62268 | biostudies-arrayexpress
TranscriptomicsIn embryo analysis of H3K27 trimethylation suggests a two-step process involving PRC2 interacting sequences and high GC content
ABSTRACT Polycomb group (PcG) proteins are essential for the repression of key developmental regulators during development. In Drosophila, the polycomb repressive complexes (PRC) associate with defined DNA sequences termed polycomb response elements (PREs). In mammals, however, the mechanisms under...
ORGANISM(S): Mus musculus 
2015-01-27 | E-GEOD-43915 | biostudies-arrayexpress
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