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MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
TranscriptomicsRNA messengers translated at the ER membrane
In order to identify what RNA messengers are being translated at the ER membrane, membrane-associated polysomes were separated from free polysomes by subcellular fractionation of WT and delta-egd1/delta-egd2 yeast strains and associated RNA was isolated and then identified by microarray analysis. Se...
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45795 | biostudies-arrayexpress
TranscriptomicsRNA coimmunoprecipitations
Nascent polypeptides emerging from the ribosome during biogenesis can interact with many chaperones and protein homeostasis factors. The high sensitivity of RNA identification can be used to identify substrates of specific cotranslationally acting chaperones. Protein A-tagged (TAP-tag) chaperones as...
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45794 | biostudies-arrayexpress
TranscriptomicsDefining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45798 | biostudies-arrayexpress
UnknownSex Differences in Long COVID.
Not available
S-EPMC11755195 | biostudies-literature
UnknownNovel evidence-based systemic lupus erythematosus responder index.
Not available
S-EPMC2748175 | biostudies-literature
GenomicsDiabetes Control and Complications Trial (DCCT) and Epidemiology of Diabetes Interventions and Complications Study (EDIC)

The Diabetes Control and Complications Trial (DCCT, 1982-93) and the Epidemiology of Diabetes Interventions and Complications follow-up study (EDIC, 1994-2016) have been ongoing for more than twenty years. After a mean follow-up of approximately 16 years, the DCCT-EDIC cohort of 1,441 Ty...

phs000086.v2.p1 | EGA
UnknownHuman IgE mAbs define variability in commercial Aspergillus extract allergen composition.
Not available
S-EPMC6237483 | biostudies-literature
TranscriptomicsTranscription profiling of expression diversity in Arabidopsis thaliana
The study of natural genetic variation for plant disease resistance responses is a complementary approach to utilizing mutants to elucidate genetic pathways. While some key genes involved in pathways controlling disease resistance, and signaling intermediates such as salicylic acid and jasmonic aci...
ORGANISM(S): Arabidopsis thaliana 
2005-10-26 | E-TABM-51 | biostudies-arrayexpress
GenomicsEpigenetic Profiling of Human Colorectal Cancer

DNA methylation, together with chromatin modifications, constitute the epigenome that functions to regulate gene expression and genome integrity. DNA methylation alterations are ubiquitous in human cancers, as many genes acquire DNA methylation in a cancer-specific manner. DNA methylation at thes...

phs000385.v1.p1 | EGA
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