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ProteomicsTyrosine phosphorylation site-specific interactome of adaptor protein Shc1 explored by synthetic protein domains
As a critical adaptor protein, Shc1 contains SH2 and PTB domains for scaffolding tyrosine phosphorylation-dependent protein complexes, therefore regulating growth factor receptor signaling networks. The three tyrosine phosphorylation sites (pY) on the CH1 linker region of SHC1 provide additional doc...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-08-15 | PXD049113 | Pride
Tyrosine phosphorylation Signal transduction Shc1 Mass spectrometry Ch1 region 
Proteomics[HPP-2.0] Integrated and high-throughput approach for sensitive analysis of tyrosine phosphoproteome
In this study, we developed a 96-well microplate-based approach to integrate all the sample preparation steps starting from cell culture to MS-compatible pTyr peptide enrichment in three consecutive 96-well microplates. By assembling engineered SH2 domain onto microplate, non-specific adsorption of ...
ORGANISM(S): Homo Sapiens 
2024-02-03 | PXD049140 |
ProteomicsDynamic phosphotyrosine-dependent signaling profiling in living cells by two-dimensional proximity proteomics
Tyrosine phosphorylation (pTyr)-dependent signaling pathways play a vital role in various biological processes, which are spatiotemporally assembled and dynamically regulated on minute-scale by pTyr in living cells. Studying these pTyr-mediated signaling complexes is therefore challenging due to the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-06 | MSV000089826 | MassIVE
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