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ProteomicsProteomic analysis of the role of the quality control protease LONP1 in mitochondrial protein aggregation
The mitochondrial matrix protease LONP1 is an essential part of the organellar protein quality control system. LONP1 has been shown to be involved in respiration control and apoptosis. Furthermore, a reduction in LONP1 level correlates with ageing processes. Up to now, the effects of a LONP1 defect ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-31 | PXD026941 | Pride
Human Protein aggregation Heat stress Lonp1 atp-dependent protease Mitochondria Genetic alteration via crispr/cas Protein degradation 
Proteomicsmetabolic reprogramming induced by LONP1 in prostate cancer is closely coupled with disease progression
To understand how Lon protease 1(Lonp1) knockin promotes prostate cancer metastasis in vivo, we performed proteomic analysis on prostates extracted from 40-week-old wild-type (WT), Lonp1KI, Pten-/- and Pten-/-; Lonp1KI mice.
ORGANISM(S): Mus Musculus 
2024-06-12 | PXD053059 |
ProteomicsQuantitative proteomics analysis of liver from LONP1 Knockout mice
The mechanisms of hepatic stellate cell (HSC) activation and the development of liver fibrosis remains largely unknow. Here, we revealed a fibrosis related mechanism of hepatocytes-HSCs crosstalk regulated by hepatocyte LONP1. We demonstrate that hepatocyte LONP1 expression is decreased in HFD-fed m...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-23 | PXD055467 | Pride
Lonp1  hepatic stellate cell  liver fibrosis  orotic acid 
TranscriptomicsTranscriptomic analysis on prostate tissues uncover the diverse gene expression features induced by Lonp1
Lon protease 1 (LONP1) is an ATP-dependent protease located in the mitochondrial matrix and plays a crucial role in regulating mitochondrial proteostasis, metabolism and cellular stress responses. Here we show that overexpression of LONP1 is closely related to adverse clinicopathological features an...
ORGANISM(S): Mus musculus 
2025-02-26 | GSE268736 | GEO
UnknownInhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives.
Not available
S-EPMC8921294 | biostudies-literature
UnknownCODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.
Not available
S-EPMC4289676 | biostudies-literature
UnknownLONP1 de novo dominant mutation causes mitochondrial encephalopathy with loss of LONP1 chaperone activity and excessive LONP1 proteolytic activity.
Not available
S-EPMC8628847 | biostudies-literature
UnknownThe mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals.
Not available
S-EPMC8733232 | biostudies-literature
GenomicsTranscriptomic analysis on prostate tissues uncover the diverse gene expression features induced by Lonp1
Transcriptomic analysis on prostate tissues uncover the diverse gene expression features induced by Lonp1
PRJNA1118336 | ENA
UnknownATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis.
Not available
S-EPMC4840290 | biostudies-literature
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