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ProteomicsAn optimized and robust workflow for quantifying the canonical histone ubiquitination marks H2AK119ub and H2BK120ub by LC-MS/MS
The eukaryotic genome is packaged around histone proteins, which are subject to a myriad of post-translational modifications. By controlling DNA accessibility and the recruitment of protein complexes that mediate chromatin-related processes, these modifications constitute a key mechanism of epigenet...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-12-10 | PXD053212 | panorama
ProteomicsMudPIT analyses of whole cell extracts from Y1 murine adrenocortical carcinoma cell line stimulated with serum or FGF2
Fibroblast growth factor 2 (FGF2) is well known as a promoter of cell proliferation, however, in some cellular contexts, it can induce cell cycle arrest or cell death. In Y1 murine adrenocortical carcinoma cell line, FGF2 induces G0/G1 transition but delays S-phase progression and permanently block ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-10-23 | MSV000081638 | MassIVE
ProteomicsTime course treatment with Palmitate and thapsigargin of insulinoma INS-1E cells
Time course treatment with 0.4 mM Palmitate and 200 nM thapsigargin of insulinoma INS-1E cells. Timepoints; 0, 4, 16 and 24h in biological duplicates within an iTRAQ 8 set for palmitate and thapsigargin, respectively.
ORGANISM(S): Rattus Rattus (black Rat) 
2020-08-18 | PXD020851 | JPOST Repository
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (Nucleoli TMT)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-12 | MSV000090518 | MassIVE
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (CLASP MudPIT data)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-12 | MSV000090516 | MassIVE
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (Chromatin MudPIT data)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-11 | MSV000090511 | MassIVE
ProteomicsMultisite proteome provides insights into the biology and prognostic markers for head and neck cancer
The poor prognosis of head and neck cancer (HNC) is largely associated with the presence of metastasis in the lymph nodes (LN). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN tissues, saliva, and blood cells, reveals insights into the bio...
ORGANISM(S): Homo Sapiens 
2022-11-22 | PXD027984 | panorama
ProteomicsMultisite proteome provides insights into the biology and prognostic markers for head and neck cancer
The poor prognosis of head and neck cancer (HNC) is largely associated with the presence of metastasis in the lymph nodes (LN). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN tissues, saliva, and blood cells, reveals insights into the bio...
ORGANISM(S): Homo Sapiens 
2022-11-22 | PXD036311 | panorama
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