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ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
TranscriptomicsTranscription profiling of human brain endothelial cells treated with TNF then incubated with platelets, P.falciparum-parasited red blood cells or normal red blood cells
HBEC-5i (human brain endothelial cells) grown to confluence in 6-well tissue culture plates. Cocultures were either left unstimulated or incubated overnight with recombinant TNF?. HBEC were then washed in PBS and incubated with PLT (platelets), pRBC (P.falciparum-parasited red blood cells) or NRBC (...
ORGANISM(S): Homo sapiens 
2009-01-15 | E-MEXP-1989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CEBPalpha and CEBPbeta null and/or mutant alleles to investigate epidermal development
Effect of CEBPalpha and CEBPbeta null and/or mutant alleles on epidermal development
ORGANISM(S): Mus musculus 
2009-09-21 | E-MEXP-1719 | biostudies-arrayexpress
TranscriptomicsIdentification of ETO2-GLIS2 transcriptional targets
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-05 | E-MTAB-4332 | biostudies-arrayexpress
UnknownKlebsiella pneumoniae sequence type 11 from companion animals bearing ArmA methyltransferase, DHA-1 β-lactamase, and QnrB4.
Not available
S-EPMC3754351 | biostudies-literature
TranscriptomicsB-cell tumor development in Tet2-deficient mice
The TET2 gene encodes an α-ketoglutarate-dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies. TET2 somatic mutations are also id...
ORGANISM(S): Mus musculus 
2019-12-12 | E-MTAB-8501 | biostudies-arrayexpress
TranscriptomicsIdentification of the epithelial receptor for measles virus
Measles (MV) is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. While it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to initially infect macrophages and dendr...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-32155 | biostudies-arrayexpress
UnknownDeep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers.
Not available
S-EPMC8611673 | biostudies-literature
UnknownGenetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice.
Not available
S-EPMC8103034 | biostudies-literature
TranscriptomicsOntogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia - scRNAseq - 2
Paediatric cancers present specific genetic alterations, however the principles underlying their differences to adult cancers are yet unclear. Poor prognosis paediatric myeloid leukaemia fusion oncogenes represent clinically-relevant models to investigate age-specific tumorigenesis. Here, we establi...
ORGANISM(S): Mus musculus 
2019-10-15 | E-MTAB-8360 | biostudies-arrayexpress
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