Methionine adenosyltransferase 1a (Mat1a) is responsible for hepatic biosynthesis of S-adenosyl-L-methionine (SAMe), the principal cellular methyl donor. Mat1a -/- mice have decreased hepatic SAMe levels, and spontaneously develop nonalcoholic steatohepatitis (NASH) which can be reversed with exogen...
ORGANISM(S): Homo Sapiens Mus Musculus
