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TranscriptomicsLysophosphatidic acid receptor expression identifies a pure population of adult hippocampal stem cells with an immune cell-related transcriptional profile
Lysophosphatidic acid receptor 1 (LPA1) is a phospholipid which has been linked to adult hippocampal neurogenesis and learning deficits. Here we investigated whether LPA acts directly on the hippocampal stem cells and whether LPA1 could be a functional marker for their prospective isolation. Our res...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-68270 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of long term potentiation in rat dentate gyrus
In vivo high frequency stimulated of left dentate gyrus was performed on anaesthetised rats followed by RNA-seq to study long-term potentiation. Both left and right dentate gyrus was collected, sequenced and compared against each other for naive rats and for rats 30 min, 2 hours, and 5 hours post-HF...
ORGANISM(S): Rattus norvegicus 
2015-10-20 | E-MTAB-3375 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hippocampus following brain infarction and treatment with various compounds
To reveal the comparative pharmacological mechanism of differential compounds and its combination, we used a custom cNDA microarray to screen gene expression on ischemia mouse hippocampus. Cerebral ischemia was induced in anesthetized mice by urethane (1.5g/kg, i.p) to 38-48g male or female mice by ...
ORGANISM(S): Mus musculus 
2010-01-01 | E-TABM-612 | biostudies-arrayexpress
TranscriptomicsOxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
To identify the detailed molecular causes of the mitochondrial dysfunction, oxidative burden and more vulnerable redox balance in Rett mouse hippocampus, we screened for differential gene expression in the hippocampal CA1 subfield of adult male mice. A whole mouse genome microarray was performed to ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-32870 | biostudies-arrayexpress
TranscriptomicsDNA-methylation of LTP-associated genes.
Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene transcription is known to be required in the formation of stable LTP, the molecular mechanisms underlying synaptic plasticity remain elusive.This study i...
ORGANISM(S): Rattus norvegicus 
2017-03-16 | E-MTAB-4919 | biostudies-arrayexpress
TranscriptomicsEarly Mechanisms of Pathobiology are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice
Prion diseases typically have long pre-clinical incubation periods during which time the infectious prion particle and infectivity steadily propagate in the brain. Abnormal neuritic sprouting and synaptic deficits are apparent during pre-clinical disease, however, gross neuronal loss is not detected...
ORGANISM(S): Mus musculus 
2012-11-09 | E-GEOD-34530 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hippocampus following experimentally induced stroke
To explore the inner mechanism of components and combination of Qingkailing inject fluid,compare the gene express and pharmacological pathway after experimental stroke mice.
ORGANISM(S): Mus musculus 
2010-12-30 | E-TABM-662 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes after treatment with chemotherapy in breast cancer and their correlation with pathologic mid-response (Miller & Payne grade 3)
The aim of this study was to compare the gene expression profile changes breast tumors after the treatment with Anthracyclines and Taxanes. To this end, an oligonucleotide microarray was performed (AffymetrixM-bM-^@M-^Ys HG-U133 Plus 2.0 array). This gene expression study was carried out on the biop...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-28583 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes after treatment with chemotherapy in breast cancer and their correlation with pathologic good response (Miller & Payne grades 4 and 5)
The aim of this study was to compare the gene expression profile changes breast tumors after the treatment with Anthracyclines and Taxanes. To this end, an oligonucleotide microarray was performed (AffymetrixM-bM-^@M-^Ys HG-U133 Plus 2.0 array). This gene expression study was carried out on the biop...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-28694 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes after treatment with chemotherapy in breast cancer and their correlation with pathologic bad response (Miller & Payne grades 1 and 2)
The aim of this study was to compare the gene expression profile changes breast tumors after the treatment with Anthracyclines and Taxanes. To this end, an oligonucleotide microarray was performed (AffymetrixM-bM-^@M-^Ys HG-U133 Plus 2.0 array). This gene expression study was carried out on the biop...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-28826 | biostudies-arrayexpress
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