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ProteomicsGSK3-Mediated Phosphorylation of DEK3 Regulates Chromatin Accessibility and Stress Tolerance in Arabidopsis
Chromatin dynamics enables the precise control of transcriptional programs. The balance between restricting and opening of regulatory sequences on the DNA needs to be adjusted to prevailing conditions and is fine-tuned by chromatin remodelling proteins. DEK is an evolutionarily conserved chromatin a...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-09-14 | PXD027308 | Pride
Chromatin / dek / protein kinase / transcription / salt stress signalling 
TranscriptomicsContribution of Veillonella parvula to Pseudomonas aeruginosa mediated pathogenicity in a murine tumor model system
We investigated the specific interactions of the most dominant bacterial CF-pathogen, Pseudomonas aeruginosa, and the anaerobic bacterium Veilllonella parvula, that has been recovered at comparable cell numbers in the respiratory tract of CF patients. We used our recently established in-vivo murine ...
ORGANISM(S): Veillonella parvula DSM 2008 
2014-11-06 | E-GEOD-58388 | biostudies-arrayexpress
TranscriptomicsSilencing of GATA3 defines a novel stem cell like subgroup of ETP-ALL
Genome wide expression profiling was used to detect cases of adult T-ALL lacking GATA3 expression. GATA3low T-ALL exhibited enrichment of myeloid/lymphoid progenitor (MLP) and granulocyte/monocyte progenitor (GMP) genes, while T-cell specific signatures were downregulated. Among upregulated genes FL...
ORGANISM(S): Homo sapiens 
2016-02-26 | E-GEOD-78132 | biostudies-arrayexpress
TranscriptomicsTranslocations Activating IRF4 Identify a Subtype of Germinal-Center-Derived B-cell Lymphoma Affecting Predominantly Children and Young Adults
Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-22470 | biostudies-arrayexpress
GenomicsNINDS-Genome-Wide Genotyping in Parkinson's Disease: First Stage Analysis and Public Release of Data

Epidemiological studies have estimated a cumulative prevalence of PD of greater than 1 per thousand. When prevalence is limited to senior populations, this proportion increases nearly 10-fold. The estimated genetic risk ratio for PD is approximately 1.7 (70% increased risk for PD if a sibling...

phs000089.v3.p2 | EGA
UnknownInfluence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course.
Not available
S-EPMC6912490 | biostudies-literature
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