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Genomicsena-DATASET-VUMC-CCA-26-05-2021-09:58:48:372-433 - samples
Control cohort of lymphoma samples sequenced with a hybrid capture panel designed to be able to detect translocations and mutations in lymphoma samples. used in the paper "Robust detection of translocations in lymphoma FFPE samples using Targeted Locus Capture-based sequencing"
EGAD00001007711 | EGA
GenomicsRobust detection of translocations in lymphoma FFPE samples using Targeted Locus Capture-based sequencing - NGS targeted capture control cohort
In routine diagnostic pathology, cancer biopsies are preserved by Formalin-Fixed, Paraffin-Embedding (FFPE) procedures for examination of (intra-) cellular morphology. Such procedures inadvertently induce DNA fragmentation, which compromises sequencing-based analyses of chromosomal rearrangements. Y...
EGAS00001005325 | EGA
TranscriptomicsLineage-specific functions of TET1 in the post-implantation mouse embryo
The TET dioxygenases erase mediate DNA dedemethylation in pre-implantation embryos and in primordial germ cells, yet limited studies address their contribution to the global gain of DNA methylation following implantation. Here, we show that Tet1 is expressed and non-redundantly contributes to 5-hydr...
ORGANISM(S): Mus musculus 
2017-05-15 | E-GEOD-71744 | biostudies-arrayexpress
TranscriptomicsRole of PsaR of Streptococcus pneumoniae D39 and TIGR4 in global gene expression and virulence
Previous studies have indicated that PsaR of Streptococcus pneumoniae is a manganese-dependent regulator, negatively affecting the expression of at least seven genes. Here, we extended these observations by transcriptome and proteome analysis of psaR mutants in strains D39 and TIGR4. The microarray ...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-15 | E-GEOD-13505 | biostudies-arrayexpress
TranscriptomicsCodY of Streptococcus pneumoniae: link between nutritional gene regulation and virulence
CodY is a nutritional regulator mainly involved in amino acid metabolism. It has been extensively studied in Bacillis subtilis and Lactococcus lactis. We investigated the role of CodY in gene regulation and virulence of the human pathogen Streptococcus pneumoniae. We constructed a codY-mutant and ex...
ORGANISM(S): Streptococcus pneumoniae TIGR4 
2010-05-25 | E-GEOD-7350 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of arabinose fermentation by engineered Saccharomyces cerevisiae
Saccharomyces cerevisiae IMS0002 which, after metabolic and evolutionary engineering, ferments the pentose sugar arabinose. Glucose and arabinose-limited anaerobic chemostat cultures of IMS0002 and its non-evolved ancestor IMS0001 were subjected to transcriptome analysis to identify key genetic chan...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-01 | E-GEOD-27539 | biostudies-arrayexpress
TranscriptomicsStranded Total RNA-seq of liver biopsy collected from Holstein Friesian cows
To explore potential functional genes related to milk production traits in cow, we performed total RNA-seq using liver biospy collected from 77 Holstein Friesian cows at postpartum 2 weeks.
ORGANISM(S): Bos taurus 
2021-07-09 | E-MTAB-9871 | biostudies-arrayexpress
TranscriptomicsWild type vs glnPA double mutant
This microarray experiment is part of a study addressing the importance of glutamine metabolism in Streptococcus pneumoniae for the virulence of this bacterium. To be able to gain more insight into the phenotype of a double mutant of glnA (TIGR 4 locus tag SP0502, encoding glutamine synthetase) and ...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-26 | E-GEOD-9850 | biostudies-arrayexpress
TranscriptomicsCardiomyocyte-specific Nitric Oxide Synthase 3 Overexpression in Pressure-Overloaded Left Ventricle.
Aims: Cardiomyocyte-specific nitric oxide synthase 3 (NOS3) overexpression reduces left ventricular (LV) remodelling after myocardial infarction in mice, but its effect on sustained LV pressure-overload remains incompletely understood. We investigated LV structural and functional adaptation to eleva...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-37597 | biostudies-arrayexpress
UnknownGenome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Not available
S-EPMC5414044 | biostudies-literature
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