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TranscriptomicsAdult T-cell leukemia-lymphoma and AZT-IFNa combination therapy
Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from 9 patients with ATLL at the time of diagnosis and immediately after combination therapy with zidovudine (AZT) ...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19160 | biostudies-arrayexpress
UnknownMYORG is associated with recessive primary familial brain calcification.
Not available
S-EPMC6331209 | biostudies-literature
TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
TranscriptomicsHGAL Enhances BCR-mediated Syk Activation, Leading to Lymphoid Hyperplasia and Amyloidosis
Gene expression data from CD22+B220+ FACS-purified splenocytes of adult Sca1-HGAL knock-in CBAxC57BL/6J mice or wild-type littermates. Transgenic mice expressing HGAL (GCET2) under control of the Sca1 (Ly-6E.1) promoter were generated. CD22 and B220 dual-positive B-cells were FACS purified from sple...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-35400 | biostudies-arrayexpress
UnknownTransient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.
Not available
S-EPMC4321731 | biostudies-literature
UnknownMicroRNAs are independent predictors of outcome in diffuse large B-cell lymphoma patients treated with R-CHOP.
Not available
S-EPMC3117929 | biostudies-literature
UnknownA cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Not available
S-EPMC3145731 | biostudies-literature
GenomicsGenetic Basis of Hepatosplenic T Cell Lymphoma (HSTL)
Hepatosplenic T cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown.  Through whole exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy number alterations in the disease. Chromatin modifying genes including SETD2, INO80 an...
EGAS00001002182 | EGA
UnknownIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.
Not available
S-EPMC3369683 | biostudies-literature
TranscriptomicsDiffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history refle...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-60 | biostudies-arrayexpress
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