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UnknownPhase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas.
Not available
S-EPMC3867644 | biostudies-literature
TranscriptomicsHGAL Enhances BCR-mediated Syk Activation, Leading to Lymphoid Hyperplasia and Amyloidosis
Gene expression data from CD22+B220+ FACS-purified splenocytes of adult Sca1-HGAL knock-in CBAxC57BL/6J mice or wild-type littermates. Transgenic mice expressing HGAL (GCET2) under control of the Sca1 (Ly-6E.1) promoter were generated. CD22 and B220 dual-positive B-cells were FACS purified from sple...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-35400 | biostudies-arrayexpress
Genomicsena-DATASET-DAVELAB-22-03-2017-21:30:50:663-38 - samples
Whole exome sequencing of hepatosplenic T cell lymphoma (HSTL) tumors, paired normals, and cell lines, including (1) 68 exome capture, paired-end Illumina Hiseq sequencing, BAM files from HSTL tumor samples, (2) 20 exome capture, paired-end Illumina Hiseq sequencing, BAM files from HSTL paired norma...
EGAD00001003246 | EGA
GenomicsGenetic Basis of Hepatosplenic T Cell Lymphoma (HSTL)
Hepatosplenic T cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown.  Through whole exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy number alterations in the disease. Chromatin modifying genes including SETD2, INO80 an...
EGAS00001002182 | EGA
GenomicsDAC for Dave Lab, Duke University
Data Access Committee EGAC00001000538
EGAC00001000538 | EGA
TranscriptomicsA mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset]
Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor ...
ORGANISM(S): Mus musculus 
2012-07-09 | E-GEOD-25636 | biostudies-arrayexpress
TranscriptomicsA mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [Spleen dataset]
Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor ...
ORGANISM(S): Mus musculus 
2012-07-09 | E-GEOD-25637 | biostudies-arrayexpress
TranscriptomicsA mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MALT dataset]
Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor ...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-25638 | biostudies-arrayexpress
TranscriptomicsLMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [preleukemic and leukemic cells]
We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 mice and in preleukemic cells from Sca1-TOMATO-Lmo2 mice. Tumor-bearing thymus of eleven Sca1-TOMATO-Lmo2 mice compared with thymus cells from 4 WT mice, with TOMATO-positive thymus preleukemic T cells from...
ORGANISM(S): Mus musculus 
2016-06-22 | E-GEOD-83570 | biostudies-arrayexpress
TranscriptomicsLMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [nude mice]
We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 Nu/Nu mice Tumor-bearing bone marrows of three Sca1-TOMATO-Lmo2 Nu/Nu mice compared with bone marrow cells from four Control Nude mice and with thymus leukemic cells from ten Sca1-TOMATO-Lmo2 mice. GSM22097...
ORGANISM(S): Mus musculus 
2016-06-22 | E-GEOD-83571 | biostudies-arrayexpress
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