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TranscriptomicsExon-level expression profiling of normal colonic mucosa samples.
These samples have been analyzed for global alternative splicing variation on exon-level expression data using the FIRMA algorithm. We have identified and described transcriptome instability as a genome-wide, pre-mRNA splicing related characteristic of solid cancers. This Series consists of 19 norma...
ORGANISM(S): Homo sapiens 
2014-08-13 | E-GEOD-42690 | biostudies-arrayexpress
TranscriptomicsLarge scale screening for fusion genes in sarcoma patient samples
We have utilized our custom array GPL11054 to screen a set of sarcoma patient samples for fusion genes One negative control was included in the study. We wanted to investigate the power of our fusion-gene array GPL11054 as a means for fusion gene detection in a series of sarcoma patient samples from...
ORGANISM(S): Homo sapiens 
2013-10-23 | E-GEOD-43632 | biostudies-arrayexpress
TranscriptomicsPilot-study for a novel universal tool for detection of oncogenic fusion transcripts
A novel oligonucleotide microarray design is described whereby one can screen for all known oncogenic fusion transcripts by one microarray hybridization. Measurements of chimeric transcript junctions are combined with exon-wise measurements of individual fusion partners. Keywords: Nimblegen custom-...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-14435 | biostudies-arrayexpress
TranscriptomicsLarge scale screening for known fusion genes in cancer cell lines
We have utilized a version 2.0 of our Fusion gene microarray (version 1.0 described by PMID: 19152679 and GEO, GPL8078) to screen cancer cell lines for known fusion genes We assembled a comprehensive database of published fusion genes, including those which have been reported only in individual stud...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-24737 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of colorectal cancer samples from patients diagnosed at a young and elderly age
Colorectal cancer (CRC) incidence increases with age and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30 % of all CRC cases. To identify genes associated with an increased risk for CRC, genome-wide gene expression levels of CRCs from patients diagno...
ORGANISM(S): Homo sapiens 
2011-09-06 | E-GEOD-25071 | biostudies-arrayexpress
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