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TranscriptomicsChanges in gene expression after epigentic targeted therapy in T-cell prolymphocytic leukemia (T-PLL)
Epigenetic therapy overcame alemtuzumab resistance in patients with relapsed T-cell prolymphocytic leukemia and induced the expression of treatment related genes. Method: patient PBMCs from Ficoll, normal patient PBMCS enriched for CD3+/CD8+ or CD3+/CD8+/CD45RA+/CCR7- were extracted in Trizol. Con...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-67368 | biostudies-arrayexpress
ProteomicsVincristine resistance reshapes sphingolipid composition and promotes mitochondrial complex I deficiency in acute myelogenous leukemia
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actio...
ORGANISM(S): Homo Sapiens (human) 
2022-04-21 | PXD025645 | JPOST Repository
ModelsT-LGL Survival Network 2011
The blood cancer T cell large granular lymphocyte (T-LGL) leukemia is a chronic disease characterized by a clonal proliferation of cytotoxic T cells. As no curative therapy is yet known for this disease, identification of potential therapeutic targets is of immense importance. In this paper, we perf...
2407 | Cell Collective
ModelsT-LGL Survival Network 2011 Reduced Network
The blood cancer T cell large granular lymphocyte (T-LGL) leukemia is a chronic disease characterized by a clonal proliferation of cytotoxic T cells. As no curative therapy is yet known for this disease, identification of potential therapeutic targets is of immense importance. In this paper, we perf...
8227 | Cell Collective
UnknownCCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.
Not available
S-EPMC9117519 | biostudies-literature
UnknownIdentification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma.
Not available
S-EPMC9414823 | biostudies-literature
ModelsMetabolic Interactions in the Gut Microbiome
We present a novel methodology to construct a Boolean dynamic model from time series metagenomic information and integrate this modeling with genome-scale metabolic network reconstructions to identify metabolic underpinnings for microbial interactions. We apply this in the context of a critical heal...
5731 | Cell Collective
ModelsT-LGL Survival Network 2008
T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that determine the survival of CTL in T-LGL leukemia, we constructed a T-LGL survival signaling network by inte...
2176 | Cell Collective
UnknownMulticentre prospective cohort study of body mass index and postoperative complications following gastrointestinal surgery.
Not available
S-EPMC4973675 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
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