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TranscriptomicsRelA and RelB-dependent transcriptome analysis in lymphotoxin-ß receptor stimulated mouse embryonic fibroblasts
Background: Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in several biological processes, ranging from development of secondary lymphoid organs, maintenance of splenic tissue, host defense against pathogens, autoimmunity, and lipid homeostasis. The major transcript...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-11963 | biostudies-arrayexpress
Transcriptomicsp100 deficiency alone is insufficient for full activation of the alternative NF-?B pathway: TNF signaling cooperates with p52-RelB activation in the transcriptional regulation of the enpp2/autotaxin promoter
Background: Constitutive activation of the alternative NF-?B pathway leads to marginal zone B cell expansion and disorganized spleen microarchitecture. Furthermore, uncontrolled alternative NF-?B signaling results in the development and progression of cancer. We aimed here to learn about the mechani...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-30317 | biostudies-arrayexpress
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