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ProteomicsSpatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors
Precise dissection of DNA-protein interactions is essential for elucidating recognition basis, dynamics, and gene regulation mechanism. However, global profiling of weak and dynamic DNA-protein interactions remains a long-standing challenge. Here, we establish light-induced lysine (K) enabled crossl...
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039229 |
MetabolomicsEpimedium-Derived Extracellular Vesicles Alleviate Cisplatin-induced Acute Kidney Injury: Integrated Multi-Omics Analysis and Molecular Simulations Reveal Flavonoid Interactions with PPARα
This study explores the protective effects and potential underlying mechanisms of Epimedium-derived extracellular vesicles (EpEVs) against cisplatin-induced acute kidney injury (CIAKI) in mice. EpEVs were isolated and purified via differential centrifugation combined with sucrose and iodixanol gradi...
2026-09-02 | MTBLS15534 | MetaboLights
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053871 | Pride
Hdx-ms Low affinity interactions Fragments 
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053877 | Pride
Hdx-ms Low affinity interactions Fragments 
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053875 | Pride
Hdx-ms Low affinity interactions Fragments 
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053852 | Pride
Hdx-ms Low affinity interactions Fragments 
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053851 | Pride
Hdx-ms Low affinity interactions Fragments 
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053847 | Pride
Hdx-ms Low affinity interactions Fragments 
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053846 | Pride
Hdx-ms Low affinity interactions Fragments 
ProteomicsPushing the Limits of Hydrogen/Deuterium Exchange Mass Spectrometry to Study Protein:Fragment Low Affinity Interactions
Characterization of protein-ligand interactions is essential for the pre-clinical development of drug candidates and Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) has emerged as a valuable tool in this process. HDX-MS has predominantly been employed with high affinity compounds with only a ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD053849 | Pride
Hdx-ms Low affinity interactions Fragments 
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