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GenomicsCohesin releases DNA through asymmetric ATPase-driven ring opening
Cohesin stably holds together the sister chromatids from S phase until mitosis. To do so, cohesin must be protected against its cellular antagonist Wapl. Eco1 acetylates cohesin’s Smc3 subunit, which locks together the sister DNAs. We used yeast genetics to dissect how Wapl drives cohesin from chr...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-18 | E-GEOD-76891 | biostudies-arrayexpress
GenomicsBiological chromodynamics: a general method for measuring protein occupancy across the genome by calibrating ChIP-seq
Sequencing DNA fragments associated with proteins following in vivo cross-linking with formaldehyde (known as ChIP-seq) has been used extensively to describe the distribution of proteins across genomes. It is not widely appreciated that this method merely estimates a protein’s distribution and canno...
ORGANISM(S): Saccharomyces cerevisiae 
2015-07-10 | E-GEOD-69907 | biostudies-arrayexpress
GenomicsReleasing activity disengages cohesin’s Smc3/Scc1 interface in a process blocked by acetylation
Sister chromatid cohesion conferred by entrapment of sister DNAs within a tripartite ring formed between cohesin’s Scc1, Smc1, and Smc3 subunits is generated during S and eventually destroyed at anaphase through cleavage of Scc1 by separase. Throughout the cell cycle, cohesin’s association with ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-18 | E-GEOD-76890 | biostudies-arrayexpress
GenomicsWhole Genome Scan for Pancreatic Cancer Risk in the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium (PanScan)

Within the framework of the NCI-sponsored Cohort Consortium, investigators from 12 prospective epidemiologic cohorts formed the Pancreatic Cancer Cohort Consortium in 2006. This study, also known as "PanScan", is funded by the National Cancer Institute (NCI) and involves conducting a genome-w...

phs000206.v3.p2 | EGA
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