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TranscriptomicsSubcutaneous adipose tissue: comparison of weight maintainence and weight regain following an 8-week low calorie diet
The present study was designed to identify determinants that foreshadow successful weight maintenance. More specifically, we examined whether subcutaneous adipose tissue (scAT) gene expression of participants who experience successful weight maintenance following caloric restriction differed from th...
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-24432 | biostudies-arrayexpress
TranscriptomicsA weekly alternating diet between caloric restriction and medium fat protects the liver from NAFLD in middle aged C57BL/6J mice
SCOPE: We investigated whether a novel dietary intervention consisting of an every-other-week calorie-restricted diet could prevent nonalcoholic fatty liver disease (NAFLD) development induced by a medium-fat (MF) diet. METHODS AND RESULTS: Nine-week-old male C57BL/6J mice received either a (i) cont...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-61233 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis reveals enhanced PKA signaling in aged skeletal muscle is suppressed by caloric restriction
Although caloric restriction (CR) was first shown to extend the lifespan of rodents over 75 years ago, the underlying mechanisms remain unclear. Additionally, the majority of published studies have focused on the effects of short-term CR. To better understand cell signaling alterations in a tissue k...
ORGANISM(S): Mus Musculus (mouse) 
2021-01-30 | PXD018455 | JPOST Repository
MetabolomicsA high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Caloric restriction (CR) delays aging-related hallmarks in various organisms by slowing growth and development while enhancing metabolic homeostasis. However, desirable diets that harness the metabolic benefits of CR without imposing food intake restrictions remain elusive. Here we evaluated the ...

2025-06-13 | MTBLS12479 | MetaboLights
TranscriptomicsTranscription profiling of four mouse tissues following acute caloric restriction
Multi-tissue transcriptional response following acute caloric restriction in mice.
ORGANISM(S): Mus musculus 
2007-05-17 | E-MEXP-748 | biostudies-arrayexpress
TranscriptomicsDifferences in genome-wide gene expression response in PBMCs between young and old men upon caloric restriction
Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different non-human organisms. Only a limited number of CR studies have been performed in humans, and results put CR as a beneficial tool to decrease risk factors in several age-related disease...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63117 | biostudies-arrayexpress
TranscriptomicsCaloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, be...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-67430 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse heart, brain, and skeletal muscle to determine the rffect of age, calorie restriction and resveratrol on gene expression
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg-1 day-1), or a calorie r...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11291 | biostudies-arrayexpress
ProteomicsExtended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
Age-related and/or high caloric intake driven changes in visceral adipose tissue contribute to the development of diabetes and cardiovascular disease. The lack of reliable, high-throughput methods to analyze the adipose tissue protein composition has limited our understanding of the protein network...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-07-03 | MSV000082569 | MassIVE
TranscriptomicsIn vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes
Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-60388 | biostudies-arrayexpress
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