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TranscriptomicsPrionic protein gene dosage is critical for maintenance of neuronal homeostasis of hippocampal circuits
We demonstrate that Prnp dosage is critical for the maintenance of neuronal homeostasis since both its absence and, more relevantly, its overexpression induce higher sensitivity to kainate (KA) damage. These data correlate with electrophysiological results in freely behaving mutant mice showing an i...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16223 | biostudies-arrayexpress
TranscriptomicsDetermination and Inference of Eukaryotic Transcription Factor Sequence Specificity
The DNA sequence preferences of the vast majority of eukaryotic transcription factors (TFs) are unknown. Using an approach designed to broadly sample both DNA-binding domain types and eukaryotic clades, we have determined DNA-binding motifs for 1,033 TFs from 131 diverse eukaryotes, encompassing 54...
ORGANISM(S): synthetic construct 
2014-08-01 | E-GEOD-53348 | biostudies-arrayexpress
UnknownColombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery - a prospective cohort study.
Not available
S-EPMC11382124 | biostudies-literature
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