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ProteomicsPKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Leucine-rich-repeat-kinase 1 (LRRK1) and its homologue LRRK2 are multidomain kinases possessing an atypical ROC-CORA-CORB containing GTPase domain and phosphorylate distinct Rab proteins. LRRK1 loss of function mutations cause the bone disorder osteosclerotic metaphyseal dysplasia, whereas LRRK2 mis...
ORGANISM(S): Homo sapiens (Human) 
2022-09-02 | PXD034420 | Pride
Rab7a Lrrk1 Pkc Phosphorylation 
MetabolomicsSex differences modulate the serum metabolome profiles in Parkinson’s disease patients harbouring pathogenic mutations in GBA1, LRRK2, TMEM175, PARK2, PINK1, and PARK7 genes

Background: Sex and genetic background have an impact on Parkinson’s disease (PD) insurgence, but the comprehension of how these factors affect the circulating profile of PD patients is still an aim of study.

Objectives: In this study we aimed to investigate whether genetic background and ...

2026-06-26 | MTBLS12753 | MetaboLights
GenomicsKnockdown LRRK1-CAPT in NCI-H1299 lung cancer cell line
Knockdown LRRK1-CAPT in NCI-H1299 lung cancer cell line
PRJNA912146 | ENA
TranscriptomicsKnockdown LRRK1-CAPT in NCI-H1299 lung cancer cell line
Knockdown LRRK1-CAPT in NCI-H1299 lung cancer cell line by two independent siRNAs, to investigate the mechanism of LRRK1-CAPT in regulation of cell proliferation.
ORGANISM(S): Homo sapiens 
2022-12-18 | GSE220952 | GEO
UnknownStructure of LRRK1 and mechanisms of autoinhibition and activation.
Not available
S-EPMC10643122 | biostudies-literature
UnknownRare variants in LRRK1 and Parkinson's disease.
Not available
S-EPMC3968516 | biostudies-literature
UnknownDifferential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Not available
S-EPMC4272680 | biostudies-literature
UnknownHeterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.
Not available
S-EPMC2847049 | biostudies-literature
UnknownLRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport.
Not available
S-EPMC9687541 | biostudies-literature
UnknownThe ULK complex-LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation.
Not available
S-EPMC9789397 | biostudies-literature
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