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UnknownThe helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.
The recognition of pathogenic DNA is important to the initiation of antiviral responses. Here we report the identification of DDX41, a member of the DEXDc family of helicases, as an intracellular DNA sensor in myeloid dendritic cells (mDCs). Knockdown of DDX41 expression by short hairpin RNA blocked...
S-EPMC3671854 | biostudies-literature
UnknownAccessibility to Digital Mental Health Services among the General Public throughout COVID-19: Trajectories, Influencing Factors and Association with Long-Term Mental Health Symptoms.
Digital mental health services (DMHSs) have great potential for mitigating the mental health burden related to COVID-19, but public accessibility (ease of acquiring services when needed) to DMHSs during the pandemic is largely unknown. Accessibility to DMHSs was tracked longitudinally among a nation...
S-EPMC8955845 | biostudies-literature
UnknownEffects of 3-HAA on HCC by Regulating the Heterogeneous Macrophages-A scRNA-Seq Analysis.
Kynurenine derivative 3-hydroxyanthranilic acid (3-HAA) is known to regulate the immune system and exhibit anti-inflammatory activity by inhibiting T-cell cytokine secretion and influencing macrophage activity. However, the definite role of 3-HAA in the immunomodulation of hepatocellular carcinoma (...
S-EPMC10238176 | biostudies-literature
UnknownMefloquine Inhibits Esophageal Squamous Cell Carcinoma Tumor Growth by Inducing Mitochondrial Autophagy.
Esophageal squamous cell carcinoma (ESCC) has a worldwide impact on human health, due to its high incidence and mortality. Therefore, identifying compounds to increase patients' survival rate is urgently needed. Mefloquine (MQ) is an FDA-approved anti-malarial drug, which has been reported to inhibi...
S-EPMC7400730 | biostudies-literature
UnknownChanges in Organic Acids, Phenolic Compounds, and Antioxidant Activities of Lemon Juice Fermented by Issatchenkia terricola.
High content of citric acid in lemon juice leads to poor sensory experience. The study aimed to investigate the dynamics changes in organic acids, phenolic compounds, and antioxidant activities of lemon juice fermented with Issatchenkia terricola WJL-G4. The sensory evaluation of fermented lemon jui...
S-EPMC8588450 | biostudies-literature
UnknownGJA1 rs2071165 A > G Variant Increased Gastric Cancer Risk in Females of Northwest China: A Case-Control Study.
Gastric cancer (GC) is one of the most common malignancies, and its incidence rates vary widely between men and women. Previous studies have suggested that connexin 43 (Cx43, encoded by gap junction protein alpha 1 (GJA1)) and secretory carrier membrane protein 1 (SCAMP1) are key functional proteins...
S-EPMC8225425 | biostudies-literature
UnknownNovel SLCO2A1 mutations cause gender-differentiated pachydermoperiostosis.
Primary hypertrophic osteoarthropathy (PHO) is a rare familial disorder with reduced penetrance for females. The genetic mutations associated with PHO have been identified in HPGD and SLCO2A1, which involved in prostaglandin E2 metabolism. Here, we report 5 PHO patients from four non-consanguineous ...
S-EPMC6223238 | biostudies-literature
UnknownNovel role of AMPK in cocaine reinforcement via regulating CRTC1.
Repeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs. Previous studies suggested a role for adenosine monophosphate-activated protein kinase (AMPK), a cellular energy sensor, in modulating neuron...
S-EPMC9805446 | biostudies-literature
UnknownUpregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer.
Approximately 70% of patients with advanced breast cancer develop bone metastases, accompanied by complications, such as bone pain, fracture, and hypercalcemia. However, our understanding of the molecular mechanisms that govern this process remains fragmentary. Osterix (Osx) is a zinc finger-contain...
S-EPMC6328543 | biostudies-literature
UnknownOligonucleotide-Driven Nanoparticle Biosensor for <i>Candida albicans</i> Detection in Vaginal Swabs.
Vulvovaginal candidiasis (VVC), caused by Candida albicans ( C.albicans ), is a common gynecological infection. VVC is traditionally diagnosed using microbiological culture and microscopy by immunofluorescence, which suffer from limitations such as time-consuming procedur...
S-EPMC12854496 | biostudies-literature
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