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TranscriptomicsTranscription profiling of human erythroblasts with the In(Lu) phenotype with normal erythroblasts.
In order to elucidate the molecular mechanism giving rise to the rare In(Lu) type of Lu(a-b-) blood group phenotype we compared the transcriptome of normal and In(Lu) erythroblasts at different stages of maturation. Many erythroid-specific genes had reduced transcript levels suggesting the phenotype...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10584 | biostudies-arrayexpress
MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
TranscriptomicsExpression analysis of human melanoma short-term culture WM451-Lu harvested after lentiviral infection with a GFP (control) or SETDB1 (experimental) viral vector
Investigation of expression differences induced by expression of the histone methyltransferase SETDB1 in human melanoma short-term culture WM451-Lu. A six-chip study using total RNA prepared from WM451-Lu melanoma short-term cultures infected with either a lentivirus encoding GFP (control) or SETDB1...
ORGANISM(S): Homo sapiens 
2011-01-07 | E-GEOD-26371 | biostudies-arrayexpress
TranscriptomicsPLZF acts as a regulator of cell-cycle genes, restricting hematopoietic stem cell proliferation and prevents hematopoietic stem cell aging.
To uncover gene programs that are regulated by PLZF in the early hematopoietic compartment, we performed micro array-based gene expression analysis of wild-type (WT) or PLZF-mutant (Zbtb16lu/lu) KSLs. DNA-microarrays were used to define and compare the transcriptional profiles of KSL cells isolated...
ORGANISM(S): Mus musculus 
2016-06-29 | E-MTAB-3682 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in murine hematopoietic stem cells
MicroRNAs influence hematopoietic differentiation, but little is known about their effects on the stem cell state. Here, we report that the microRNA processing enzyme Dicer is essential for stem cell persistence in vivo and a specific microRNA, miR-125a controls the size of the stem cell population ...
ORGANISM(S): Mus musculus 
2010-08-14 | E-GEOD-22450 | biostudies-arrayexpress
UnknownOptimization of the radiosynthesis of the PSMA-targeting drugs [<sup>177</sup>Lu]Lu-P17-087 and [<sup>177</sup>Lu]Lu-P17-088 on the MiniLu™ automated module.
Not available
S-EPMC12623512 | biostudies-literature
TranscriptomicsmicroRNA Profiling in Wilms Tumors and Kidney Tissues
The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bea...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress
UnknownComparison of the Anti-Tumour Activity of the Somatostatin Receptor (SST) Antagonist [177Lu]Lu-Satoreotide Tetraxetan and the Agonist [177Lu]Lu-DOTA-TATE in Mice Bearing AR42J SST2-Positive Tumours.
Not available
S-EPMC9506113 | biostudies-literature
UnknownEnhancing [177Lu]Lu-DOTA-TATE therapeutic efficacy in vitro by combining it with metronomic chemotherapeutics.
Not available
S-EPMC11322472 | biostudies-literature
UnknownPrediction of [177Lu]Lu-DOTA-TATE therapy response using the absorbed dose estimated from [177Lu]Lu-DOTA-TATE SPECT/CT in patients with metastatic neuroendocrine tumour.
Not available
S-EPMC10844176 | biostudies-literature
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