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ProteomicsLoss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP
The Ras GTPase-activating protein SynGAP interacts with PSD95 to regulate synaptic morphology and function at the postsynaptic density in neurons. Haploinsufficiency of SYNGAP1 has been linked to autism spectrum disorders (ASD) and intellectual disability (ID). While transcriptional and translationa...
ORGANISM(S): Mus Musculus 
PXD064040 |
ProteomicsMuscular lactate modulates phase transition-driven lactate body secretion to induce liver fibrosis during long-term overtraining
Exercise, as the fundamental therapy for metabolic diseases, often exhibits a dose-dependent fashion. However, the adverse effects of overtraining and underlying mechanisms remain unclear. Here, we show that long-term overtraining induces hepatic fibrosis in humans and mice. Mechanistically, excessi...
ORGANISM(S): Mus Musculus 
PXD052424 |
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