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ProteomicsDepletion of Mitochondrial Methionine Adenosyltransferase α1 Triggers Mitochondrial Dysfunction in Alcohol-Associated Liver Disease
Mitochondrial MATα1 is selectively depleted in alcohol-associated liver disease through a mechanism that involves the isomerase PIN1 and the kinase CK2. Alcohol activates CK2, which phosphorylates MATα1 at Ser114 facilitating interaction with PIN1, thereby inhibiting its mitochondrial localization. ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-17 | PXD030383 | Pride
Liver Matα1 Mitochondria Alcohol 
ProteomicsPINE: An Automation Tool to Extract & Visualize Functionally Enriched Networks from Mass Spectrometry-Based Proteomics Datasets
Recent surges in mass spectrometry-based proteomics studies demands a concurrent rise in speedy and optimized data processing tools and pipelines. While several stand-alone databases exist that store gene interaction and annotation information, we developed Protein Interaction Network Extractor (PIN...
ORGANISM(S): Mus Musculus 
2021-02-23 | PXD017324 | panorama
ProteomicsGlobal Hyper-Phosphorylation Characterizes Liver Disease Progression in Methionine Adenosyltransferase 1A Knockout Mice
Methionine adenosyltransferase 1a (Mat1a) is responsible for hepatic biosynthesis of S-adenosyl-L-methionine (SAMe), the principal cellular methyl donor. Mat1a -/- mice have decreased hepatic SAMe levels, and spontaneously develop nonalcoholic steatohepatitis (NASH) which can be reversed with exogen...
ORGANISM(S): Homo Sapiens Mus Musculus 
2026-06-12 | PXD022122 | panorama
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