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ProteomicsRisk SNP rs11067228-mediated high-order chromatin interactions drive prostate cancer neuroendocrine differentiation through splicing factor SRRM4
Neuroendocrine prostate cancer is an aggressive disease characterized by early metastasis, drug resistance and poor prognosis. Genome-wide association studies (GWAS) previously identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer. SNP rs11067228 as a significant...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD055628 | Pride
Snp rs11067228  enhancer  long-range chromatin interaction  neuroendocrine differentiation  prostate cancer 
TranscriptomicsLinker histone H1.2 establishes chromatin comapction and gene silencing through recognition of H3K27me3
Linker histone H1 is a protein component of chromatin and has been linked to chromatin compaction and global gene silencing.It has been sugegsted that H1 plays a significant role, regulating a relatively small number of genes. Here we show that H1.2- a variant of H1 subtype is recruited to chromati...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-68050 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling in bone marrow-derived macrophage (BMM) cells upon RANKL treatment
To screen for altered gene expression during osteoclastogenesis, RANKL-treated BMM cells were subjected to gene expression profiling. BMM cells were treated with M-CSF and RANKL for 0, 1, 2 and 3 days. Total RNA was isolated and analyzed by gene expression microarray using the MouseRef-8 v2.0 Expres...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-57468 | biostudies-arrayexpress
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