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UnknownHigh-sensitivity detection of <i>Mycobacterium tuberculosis</i> DNA in tongue swab samples.
Tongue swab (TS) sampling combined with quantitative PCR (qPCR) to detect Mycobacterium tuberculosis (MTB) DNA is a promising alternative to sputum testing for tuberculosis (TB) diagnosis. In prior studies, the sensitivity of tongue swabbing has usually been lower than sputum. In this study, ...
S-EPMC11837540 | biostudies-literature
UnknownHigh-sensitivity detection of <i>Mycobacterium tuberculosis</i> DNA in tongue swab samples.
Tongue swab (TS) sampling combined with qPCR to detect Mycobacterium tuberculosis (MTB) DNA is a promising alternative to sputum testing for tuberculosis (TB) diagnosis. In prior studies, the sensitivity of tongue swabbing has usually been lower than sputum. In this study, we evaluated two st...
S-EPMC11302704 | biostudies-literature
UnknownA double-blind, randomised, placebo-controlled, dose-finding trial of the novel tuberculosis vaccine AERAS-402, an adenovirus-vectored fusion protein, in healthy, BCG-vaccinated infants.

Background

Several novel tuberculosis vaccines are currently in clinical trials, including AERAS-402, an adenovector encoding a fusion protein of Mycobacterium tuberculosis antigens 85A, 85B, and TB10.4. A multicentred trial of AERAS-402 safety and immunogenicity in healthy infants was condu...
S-EPMC6698638 | biostudies-literature
UnknownMycobacterium tuberculosis-specific blood immune signatures distinguish sarcoidosis from tuberculosis disease.
Sarcoidosis is a granulomatous systemic inflammatory disease predominantly affecting the lungs. It shares histopathological, clinical, and immune features with tuberculosis (TB). There are currently no diagnostic tests to formally identify sarcoidosis; instead, there is a need first to rule out the ...
S-EPMC12585110 | biostudies-literature
UnknownHigh Asymptomatic Carriage With the Omicron Variant in South Africa.
We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4 + T-cell counts in persons with human immunodefi...
S-EPMC9383623 | biostudies-literature
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