Novel LUC7L-NUTM1 https://submit.ncbi.nlm.nih.gov/subs/sra/SUB13924167/bp_info#helper_relevance-public_descriptiongene fusion from translocation t(15 16)(q14 p13) in MPN-Eo with rearrangement of PDGFRA: A case report
Prion diseases are fatal neurodegenerative disorders driven by prion protein (PrP) misfolding, and lowering cellular PrP represents a promising therapeutic strategy. Here we report a small-molecule approach that reduces PrP by modulating pre-mRNA splicing of the PRNP gene. Through chemical modificat...
Microexons (exons ≤30 nts) are important features of neuronal transcriptomes, but pose mechanistic challenges to the splicing machinery. We previously showed that PRP-40, a component of the U1 spliceosome, is globally required for microexon splicing in C. elegans. Here we show that the homologous PR...
