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GenomicsGenome-wide DNA methylation profiling of mouse liver
To determine whether differences between background strains or housing conditions altered the hepatic methylome, We report the generation and analysis of genome-wide DNA methylation profiles at nucleotide resolution in mouse liver from two male mice on a mixed background (mixed-1, mixed-2) and two m...
ORGANISM(S): Mus musculus 
2016-06-13 | E-GEOD-80761 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of HCT-116 versus HCT-116 treated with 5-aza-2'-deoxycytidine processing human colon cancer cell lines
UCRs expression signature of HCT-116 cell lines versus HCT-116 cell line treated with DNA methylation inhibitor 5-aza-2'-deoxycytidine
ORGANISM(S): Homo sapiens 
2010-03-09 | E-MTAB-196 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human hepatocellular carcinoma cell line Huh7 and immortalized hepatocyte cell line THLE5B treated with experimental compound AD80, Sorafenib, and vehicle for 24 hours
To delineate the transcriptomic changes induced by AD80 relative to sorafenib, we performed RNA-sequencing (RNA-seq) on HUH7 and THLE5B cells treated for 24 hours with either DMSO, sorafenib, or AD80 near respective growth inhibitory GI50 values. HUH7 cells were plated in 6 well plates, treated for ...
ORGANISM(S): Homo sapiens 
2019-08-02 | E-MTAB-7847 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the human HCC cell line PLC5 after 72 hours treatment with either MAGEA3 shRNA or Scramble control
To better understand the mechanism by which MAGEA3 contributes to HCC progression, we conducted RNA sequencing in the PLC5 HCC cell line after 72 hours of treatment with scramble or sh8375 in triplicate. RNA-sequencing was conducted on poly-A enriched RNA, 100 bp single reads using an Illumina HiSeq...
ORGANISM(S): Homo sapiens 
2021-05-19 | E-MTAB-8860 | biostudies-arrayexpress
ProteomicsPhosphoproteomic profiling of WNTinib
Phosphoproteome profiling small molecule on sensitive and insensitive murineHCC tumour organoids
ORGANISM(S): Mus Musculus (mouse) 
2023-03-16 | PXD024958 | JPOST Repository
TranscriptomicsExpression data from proliferating and senescent murine hepatic stellate cells
The p53 protein is a cell-autonomous tumor suppressor that restricts malignant transformation by triggering cell cycle exit or apoptosis. p53 also promotes cellular senescence, a program that triggers a stable cell cycle arrest and can modify the tissue microenvironment through its effect on cell me...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-39469 | biostudies-arrayexpress
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