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ProteomicsFolding correctors can retore CFTR post-translational folding landscape by allosteric domain-domain coupling
Numerous missense mutations cause misfolding and premature degradation of ATP-binding cassette (ABC)-transporters-transporters, accounting for several human conformational diseases with poorly under-stood molecular mechanisms. Recent breakthroughs in small molecule combination therapy led transforma...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042481 | Pride
Biogenesis Post-translational protein folding Cystic fibrosis mutation Protein dynamics Coupled domain folding Hydrogen-deuterium exchange and mass spectrometry (hdx-ms) Abc-transporter Folding corrector drugs Allostery Cystic fibrosis transmembrane conductance regulator (cftr) 
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