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Transcriptomicshgu133a integrated dataset
hgu133a integrated dataset integrated from ArrayExpress and GEO
ORGANISM(S): Homo sapiens 
2007-11-20 | E-TABM-185 | biostudies-arrayexpress
TranscriptomicsHuman gene expression atlas of 5372 samples representing 369 different cell and tissue types, disease states and cell lines
The experiment contains systematically annotated and consistently normalized human gene expression data matrix of 5372 samples integrated from 206 public experiments of a HG-U133A array platform. The dataset is a subset of a larger pool of 9004 samples gathered from ArrayExpress and GEO websites and...
ORGANISM(S): Homo sapiens 
2010-08-04 | E-MTAB-62 | biostudies-arrayexpress
GenomicsCombinatorial transcription factor binding evolution in five placental mammals
Zoo-ChIP: Functional analysis of experimentally determined combinatorial transcription factor binding in multiple mammalian species
ORGANISM(S): Rattus norvegicus 
2014-09-27 | E-MTAB-1509 | biostudies-arrayexpress
GenomicsAHT-ChIP-seq, a completely automated robotic protocol to perform chromatin immunoprecipitation in high-throughput
Transcription factor binding locations by ChIP followed by high throughput sequencing. To build and validate an automated Chromatin Immunoprecipitation and high throughput Illumina sequencing pipeline
ORGANISM(S): Homo sapiens 
2013-06-01 | E-MTAB-1579 | biostudies-arrayexpress
GenomicsBioCAP-Seq analysis of human chromosome 21 after its passage through either the mouse male germline
This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chrom...
ORGANISM(S): Mus musculus 
2016-11-16 | E-MTAB-4930 | biostudies-arrayexpress
GenomicsA CpG mutational hotspot in a ONECUT (HNF6) binding site accounts for the prevalent variant of Hemophilia B Leyden
Hemophilia B, or the 'Royal Disease', arises from mutations in the Coagulation Factor IX (F9) gene. Mutations within the F9 promoter are associated with a remarkable form of the disease, termed Hemophilia B Leyden, in which symptoms ameliorate after puberty. Mutations at the -5/-6 site account for t...
ORGANISM(S): Mus musculus 
2013-03-06 | E-MTAB-890 | biostudies-arrayexpress
GenomicsChip-Seq analysis of human chromosome 21 after its passage through either the female or male mouse germline
This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chrom...
ORGANISM(S): Mus musculus 
2016-11-16 | E-MTAB-4913 | biostudies-arrayexpress
TranscriptomicsRNA-Seq in liver of Tc1 mice carrying human chromosome 21 passaged through either the female or male germline
This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chrom...
ORGANISM(S): Mus musculus 
2016-11-16 | E-MTAB-4912 | biostudies-arrayexpress
GenomicsEpigenetic comparison of human DNA in specific human tissues to human DNA in transgenic mouse tissues
This project aims to study human repetitive elements on human chromosome 21 (HsChr21) in a heterologous mouse environment (Tc1 mouse). The in vivo, HsChr21-wide enrichment of active histone modified regions (H3K4me3) and transcription factor binding sites was profiled by ChIP-seq in Human and Tc1 mo...
ORGANISM(S): Mus musculus 
2013-03-21 | E-MTAB-1104 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by array of human and TC1 and TC0 mouse strain livers and testes to study human repetitive elements on human chromosome 21 in a heterologous mouse environment
The aim of this project is to study human repetitive elements on human chromosome 21 in a heterologous mouse environment (Tc1 mouse). To determine the unbiased regulation of the human genome, suppressed regions of human chromosome 21 were identified in vivo in liver and testes of human and Tc1 mouse...
ORGANISM(S): Mus musculus 
2012-12-13 | E-MTAB-1304 | biostudies-arrayexpress
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