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TranscriptomicsGene regulation by the lysine demethylase KDM4A in Drosophila
Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified. Histone methyltransferases and demethylases ensure that histone methylations are dynamic and can vary depending on cell cycle- or developmental ...
ORGANISM(S): Drosophila melanogaster 
2013-04-01 | E-GEOD-36903 | biostudies-arrayexpress
TranscriptomicsTargeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the 4th chromosome in Drosophila melanogaster
In Drosophila melanogaster, two chromosome-specific targeting and regulatory systems have been described. The male-specific lethal (MSL) complex supports dosage compensation by stimulating gene expression from the male X-chromosome and the protein Painting of fourth (POF) specifically targets and st...
ORGANISM(S): Drosophila melanogaster 
2013-05-27 | E-GEOD-45402 | biostudies-arrayexpress
TranscriptomicsMany obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
Background: The mechanisms of how genetic variants (SNPs) identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which continue to puzzle the scientific community. Recent evidence points to epigenetic and chromatin state of the genome to have ...
ORGANISM(S): Homo sapiens 
2015-09-17 | E-GEOD-73103 | biostudies-arrayexpress
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