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ProteomicsSpatially variant immune infiltration scoring in human cancer tissues
The Immunoscore is a method to quantify the immune cell infiltration within cancers to predict the disease prognosis. Previous immune profiling approaches relied on limited immune markers to establish patients’ tumor immunity. However, immune cells exhibit a higher-level complexity that is typically...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035340 | Pride
Lung cancer imc 
ProteomicsA framework for performing single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology
Metabolic reprogramming in cancer and immune cells occurs to support their increasing energy needs in biological tissues. Here we propose Single Cell SPAtially resolved METabolic (scSpaMet) framework for joint protein-metabolite profiling of single immune and cancer cells in male human tissues by in...
ORGANISM(S): Homo sapiens (Human) 
2023-10-02 | PXD045840 | Pride
Human lung Endometrium imc imaging Tumor 
TranscriptomicsTranscription profiling of mouse EGFR mutants
We performed mRNA expression profiling of lung tumors from C/L858R, C/T790M, and C/L+T mice and from corresponding normal lung tissue. Experiment Overall Design: mRNA was extracted from pulverized lung samples using Trizol (Invitrogen) and then hybridized to MOE 430 2.0 chips (Affymetrix) using stan...
ORGANISM(S): Mus musculus 
2009-12-14 | E-GEOD-17373 | biostudies-arrayexpress
GenomicsNCTN: A Randomized Phase II Study of Cisplatin and Etoposide in combination with either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients with Extensive Stage Small Cell Lung Cancer (E1508)
NCTN: A Randomized Phase II Study of Cisplatin and Etoposide in combination with either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients with Extensive Stage Small Cell Lung Cancer (E1508)
PRJNA1526128 | ENA
GenomicsNCTN: A Randomized Phase II Study of Cisplatin and Etoposide in combination with either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients with Extensive Stage Small Cell Lung Cancer (E1508)
NCTN: A Randomized Phase II Study of Cisplatin and Etoposide in combination with either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients with Extensive Stage Small Cell Lung Cancer (E1508)
PRJNA1526129 | ENA
UnknownIMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry.
Not available
S-EPMC10036333 | biostudies-literature
UnknownCancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer.
Not available
S-EPMC10929690 | biostudies-literature
UnknownDevelopment and validation of a nomogram for predicting immune-mediated colitis in lung cancer patients treated with immune checkpoint inhibitors: a retrospective cohort study in China.
Not available
S-EPMC11821966 | biostudies-literature
TranscriptomicsActivation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
HCC827 cells were grown in gradually increasing concentrations of cetuximab beginning at 0.1 ug/ml. Drug concentrations were slowly increased until the resistant cells were able to proliferate in 100 ug/ml of cetuximab. Individual clones of cetuximab resistant (CR; CR1 to CR4) cells were isolated an...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-30255 | biostudies-arrayexpress
UnknownThe prognostic effect of infiltrating immune cells is shaped by proximal M2 macrophages in lung adenocarcinoma.
Not available
S-EPMC11373246 | biostudies-literature
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