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TranscriptomicsAlternative splicing controlled by heterogeneous nuclear ribonucleoprotein L (hnRNP L) regulates development, proliferation and migration of thymic pre-T cells
The regulation of post-transcriptional modifications of pre-mRNA by alternative splicing is important for cellular function, development and immunity The receptor tyrosine phosphatase CD45, which is expressed on all hematopoietic cells, is known for its role in the development and activation of T ce...
ORGANISM(S): Mus musculus 
2012-04-23 | E-GEOD-33306 | biostudies-arrayexpress
TranscriptomicsGene expression data for the budding yeast mutants pol30-8, dot1Δ and pol30-8 dot1Δ
The mutation in the budding yeast gene PCNA, pol30-8, as well as deletion of DOT1 (dot1Δ), encoding the only histone H3 K79 methyltransferase in budding yeast, have been implicated in telomeric silencing. To further analyze these mutants, we used microarrays to study whether either pol30-8, dot1Δ or...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-17 | E-GEOD-27222 | biostudies-arrayexpress
TranscriptomicsMutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability
K-ras mutations are observed in around 40% human colorectal adenomas and carcinomas and contribute to the pathogenesis of human and rodent colorectal tumour formation. Previously, we developed and characterised a strain of transgenic mice with inducible intestinal epithelial expression of K-rasVal12...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-24010 | biostudies-arrayexpress
TranscriptomicsTranscription profile of K-ras activated murine menstruating uteri
The expression of K-ras transgene is induced in K-rasV12+/-/Cre+/+/ROSA26R-LacZ+/+ transgenic mice uteri, which were primed with hormone treatment. Decidualization was artificially induced in these uteri and hormone injection was withdrawn to induced menstruation-like endometrial degeneration. Micr...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-15518 | biostudies-arrayexpress
UnknownPrognostic roles of KL-6 in disease severity and lung injury in COVID-19 patients: A longitudinal retrospective analysis.
Not available
S-EPMC8013517 | biostudies-literature
TranscriptomicsKnockout mice reveal key roles for claudin-18 in alveolar fluid homeostasis.
Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJ), where they serve as regulators of paracellular permeability to ions and solutes. Claudin-18, a member of the large claudin family, is highly expressed in lung epithelium. To elucidate the role of claudin-18 i...
ORGANISM(S): Mus musculus 
2014-04-06 | E-GEOD-48443 | biostudies-arrayexpress
TranscriptomicsTranscriptional signatures associated with species divergence in New Zealand Pachycladon (Brassicaceae)
Comparative gene expression profiling of a) above-ground tissues of three fruiting species (P. cheesemanii, ch, P. exile, ex, P. novae-zelandiae, nz), b) above-ground tissues of two rosette stage species (P. fastigiatum, fa, P. enysii, en) and c) roots of all five species using heterologous A. thali...
ORGANISM(S): Pachycladon exile 
2009-11-16 | E-GEOD-19017 | biostudies-arrayexpress
TranscriptomicsIllumina microarray experiment on LSD1 deletion ES cell with Lsd1Lox/Δ3 and Lsd1Δ3/Δ3
Lysine specific demethylase 1 (LSD1), which demethylates mono- and di- methylated histone H3-Lys4 as part of a complex including CoREST and histone deacetylases (HDAC), is essential for embryonic development in the mouse beyond e6.5 days. Here, we demonstrate that LSD1 expression and therefore funct...
ORGANISM(S): Mus musculus 
2010-12-06 | E-GEOD-21131 | biostudies-arrayexpress
TranscriptomicsGlycerol metabolism and PrfA activity in Listeria monocytogenes
Listeria monocytogenes is able to efficiently utilize glycerol as carbon source. In a defined minimal medium the growth rate is similar (during balanced growth) in presence of glycerol as in presence of glucose or cellobiose. Comparative transcriptome analyses of L. monocytogenes showed in the prese...
ORGANISM(S): Listeria monocytogenes 
2008-05-30 | E-GEOD-11459 | biostudies-arrayexpress
TranscriptomicsGene expression data at 24hrs post-siRNA transfection for HCT116 cultures transfected with either DDX5si2008, DDX5si2053, or EBNA1si1666 siRNA's or mock transfected.
HCT116 cells were transfected with two different siRNA's targeting either DDX5, an siRNA targeting EBNA1, or no siRNA (mock). The siRNA targeting EBNA1 is used as a negative control since HCT116 cells do not have the EBNA1 gene. RNA was obtained from cultures at 24hrs post-siRNA transfection using t...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-36141 | biostudies-arrayexpress
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