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TranscriptomicsNon-alcoholic steatohepatitis causes selective CD4+ T cell loss and promotes hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer related death. NAFLD affects a large proportion of the US population. Its incidence and prevalence are increasing to epidemic proportions around the world and is known to increase the risk of HCC. We studied how intrahepatic li...
ORGANISM(S): Mus musculus 
2016-03-10 | E-GEOD-67918 | biostudies-arrayexpress
ProteomicsA peptide-based tolerizing vaccine against autoimmune arthritis directly interacting with antigen-specific T cells
A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. Major hindrances have so far been to select natural regulatory antigen targets and side-effects induced by clustering the T cell receptor (TCR) or activating the costimulatory signa...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-15 | PXD034792 | Pride
Autoimmune arthritis Arthritis Antigen-specific t cells Vaccine 
ProteomicsProteomics of human Vγ9Vδ2-T cells treated with BSA, PA, or OA by LC-MS/MS
To better understand the mechanisms underlying the different antitumor activity of Vγ9Vδ2-T cells induced by PA or OA, we performed the proteomic analysis of Vγ9Vδ2-T cells cultured under different conditions.
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD064016 | Pride
Proteomics Human vγ9vδ2-t cells Pa or oa Lc-ms/ms 
TranscriptomicsmiRNAs expression in the splenic CD4+ T cells and B cells isolated from MRL/lpr mice at 5 and 16 weeks of age
To identify any differentially expressed miRNAs in the CD4+ T cells of lupus. MicroRNAs (miRNAs) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of posttranscriptional repression. Dysregulation of miRNAs has been described in various disease stat...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-21220 | biostudies-arrayexpress
UnknownTranslational development of a novel BAFF-R CAR-T therapy targeting B-cell lymphoid malignancies.
Not available
S-EPMC10991874 | biostudies-literature
ProteomicsTargeting PILRα, an immune checkpoint mediating T cell suppression, for cancer immunotherapy
One of the most successful therapies in cancer treatment involves immune checkpoint blockade using the anti-programmed death-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibody, which targets the interaction between tumors and T cells. However, the overall response rate is < 30% in patients wit...
ORGANISM(S): Homo Sapiens 
2024-01-25 | PXD048903 |
ProteomicsArid3b suppresses CD8+ T cell infiltration and function in Microsatellite-stable colorectal cancer via Runx3
Microsatellite stable/proficient mismatch repair (MSS/pMMR) colorectal cancer (CRC) is characterized by a cold tumor microenvironment, marked by sparse CD8⁺ T cell infiltration and resistance to immune checkpoint inhibitors (ICIs). To uncover regulators that limit CD8⁺ T cell infiltration in MSS CRC...
ORGANISM(S): Mus Musculus 
2026-04-16 | PXD077233 |
TranscriptomicsAlternative splicing controlled by heterogeneous nuclear ribonucleoprotein L (hnRNP L) regulates development, proliferation and migration of thymic pre-T cells
The regulation of post-transcriptional modifications of pre-mRNA by alternative splicing is important for cellular function, development and immunity The receptor tyrosine phosphatase CD45, which is expressed on all hematopoietic cells, is known for its role in the development and activation of T ce...
ORGANISM(S): Mus musculus 
2012-04-23 | E-GEOD-33306 | biostudies-arrayexpress
UnknownNovel allogeneic CAR T-cell platform involving microhomology-mediated end joining repair and low off-targeting potential.
Not available
S-EPMC12704299 | biostudies-literature
UnknownTargeting chronic lymphocytic leukemia with B-cell activating factor receptor CAR T cells.
Not available
S-EPMC11366826 | biostudies-literature
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