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TranscriptomicsTranscriptional activity regulates alternative cleavage and polyadenylation
Genes containing multiple polyadenylation (polyA) sites express mRNA isoforms with variable 3’ untranslated regions (3’UTRs). We found that short and long 3’UTR isoforms were relatively more abundant when genes were highly and lowly expressed, respectively, in human and mouse cells. Consistently, up...
ORGANISM(S): Mus musculus 
2011-08-15 | E-GEOD-26512 | biostudies-arrayexpress
TranscriptomicsRegulation of alternative cleavage and polyadenylation by 3’ end processing and splicing factors
Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding sequences. How core cleavage and polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA knockdown coupled with deep sequencing, we found...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-62001 | biostudies-arrayexpress
TranscriptomicsAnalysis of alternative cleavage and polyadenylation by 3' region extraction and deep sequencing
Alternative cleavage and polyadenylation (APA) generates diverse mRNA isoforms. We developed 3' region extraction and deep sequencing (3'READS) to address mispriming issues that commonly plague poly(A) site (pA) identification, and we used the method to comprehensively map pAs in the mouse genome. T...
ORGANISM(S): Mus musculus 
2012-12-17 | E-GEOD-42398 | biostudies-arrayexpress
ProteomicsIdentifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
The interaction proteins were obtained by immunoprecipitation (IP) of VWA8 using retinal pigment epithelium cell lysate.
ORGANISM(S): Homo Sapiens 
2026-03-29 | PXD076332 |
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