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The expression data utilized in this analysis derives from the raw data published by Su et al. 2004 (also known as GNF/Novartis dataset or E-AFMX-5 in ArrayExpress, GSE1133 and GDS596 in GEO). The data contains 79 different human tissues and cell types with 2 replicates per tissue/cell type. The dat...
ORGANISM(S): Homo sapiens 
Deficiency of proteostasis and RNA metabolism are increasingly recognized as critical drivers of neurodegenerative diseases. In this study, we focused on RNA polymerase II (Pol2) as the converging point of these two elements to understand how transcriptional machinery is affected by ALS-associated V...
ORGANISM(S): Homo Sapiens (human) 
iCLIP experiment to assess the binding of the highly abundant nuclear RNA-binding protein hnRNP C and core splicing factor U2AF65 on a genomic scale. To investigate how both proteins compete for binding at a subset of sites, U2AF65 iCLIP experiments were performed from both HNRNPC knockdown and cont...
ORGANISM(S): Homo sapiens 
We performed RNA-seq experiments on two replicate samples from each HNRNPC knockdown (KD1 and KD2) As well as from control HeLa cells. Library preparation was preformed according to mRNA Sequencing Sample Preparation Guide (Illumina, Part # 1004898 REV. D). Reagents were taken from the Illumina samp...
ORGANISM(S): Homo sapiens 
RNAseq to assess changes in transcript abundance upon knockdown of the RNA-binding protein Unkempt in human SH-SY5Y cell lines.
ORGANISM(S): Homo sapiens 
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