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TranscriptomicsA weekly alternating diet between caloric restriction and medium fat protects the liver from NAFLD in middle aged C57BL/6J mice
SCOPE: We investigated whether a novel dietary intervention consisting of an every-other-week calorie-restricted diet could prevent nonalcoholic fatty liver disease (NAFLD) development induced by a medium-fat (MF) diet. METHODS AND RESULTS: Nine-week-old male C57BL/6J mice received either a (i) cont...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-61233 | biostudies-arrayexpress
TranscriptomicsSexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice
There is increasing appreciation for sexually dimorphic effects, but the molecular mechanisms underlying these effects are only partially understood. In the present study, we explored transcriptomics and epigenetic differences in the small intestine and colon of prepubescent male and female mice. In...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-57516 | biostudies-arrayexpress
TranscriptomicsMaternal exposure to a Western-style diet causes differences in microbiota composition and gene expression in the intestine of suckling mouse pups
During the last few decades, the long-lasting consequences of nutritional programming during the early phase of life have become increasingly evident, but the effects of maternal nutrition on the developing intestine are currently still relatively underexplored. In this study, we investigated in mic...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-72705 | biostudies-arrayexpress
TranscriptomicsFibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice
Fibroblast growth factor 21 (Fgf21) has emerged as a potential plasma marker to diagnose non-alcoholic fatty liver disease (NAFLD). To study the molecular processes underlying the association of plasma Fgf21 with NAFLD, we explored the liver transcriptome data of a mild NAFLD model of aging C57BL/6J...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-84495 | biostudies-arrayexpress
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