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UnknownStructural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.
A subset of lupus patients with severe nephritis and anti-nRNP reactivity produces autoantibodies primarily against two major epitopes of the nRNP A (also known as U1A) protein. These sequences span amino acids 44-56 (A3) and amino acids 103-115 (A6). These two epitopes represent structurally differ...
S-EPMC373500 | biostudies-literature
UnknownGenome-wide association study and functional validation implicates JADE1 in tauopathy.
Primary age-related tauopathy (PART) is a neurodegenerative pathology with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amy...
S-EPMC8786260 | biostudies-literature
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