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TranscriptomicsRabbit heart gene expression in Left ventricle (LV) following banding of the descending thoracic aorta (AOB-LV) vs Sham-control LV and in Right ventricle (RV) following banding the pulmonary artery (PAB-RV) vs. Sham-control RV
Background: Right ventricular (RV) and left ventricular (LV) myocardium differ in their response to pressure-overload hypertrophy (POH). In this report we use microarray and proteomic analyses to identify pathways modulated by LV-, and RV-POH in the immature heart. Methods: Newborn New Zealand White...
ORGANISM(S): Oryctolagus cuniculus 
2011-06-24 | E-GEOD-30194 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of left ventricle and peripheral blood cells in rats with post-myocardial infarction
Myocardial infarction (MI) often results in left ventricular (LV) remodeling followed by heart failure (HF). It is of great clinical importance to understand the molecular mechanisms that trigger transition from compensated LV injury to HF and to identify relevant diagnostic biomarkers. In this stud...
ORGANISM(S): Rattus norvegicus 
2013-11-15 | E-GEOD-47495 | biostudies-arrayexpress
TranscriptomicsIdentifying gene expression profiles in hypoplastic left heart syndrome and age-matched normal controls
Affymetrix GeneChip Exon-1.0ST was used to study the differential gene profiles in RV (right ventricle) samples from neonates with HLHS (hypoplastic left heart syndrome) versus RV and LV (left ventricle) samples obtained from age-matched controls. Although few significant changes were observed in th...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-23959 | biostudies-arrayexpress
UnknownBiodegradation of di-n-butyl phthalate by bacterial consortium LV-1 enriched from river sludge.
Not available
S-EPMC5444784 | biostudies-literature
UnknownPeptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.
Not available
S-EPMC4382007 | biostudies-literature
TranscriptomicsTranscriptional effects of CTGF inhibition in a transgenic mouse model of dilated cardiomyopathy
Cardiac structural changes associated with dilated cardiomyopathy (DCM) include cardiomyocyte hypertrophy and myocardial fibrosis. Connective Tissue Growth Factor (CTGF) has been associated with tissue remodeling and is highly expressed in failing hearts. To test if inhibition of CTGF would alter ...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-68857 | biostudies-arrayexpress
UnknownIdentification of Peptide lv, a novel putative neuropeptide that regulates the expression of L-type voltage-gated calcium channels in photoreceptors.
Not available
S-EPMC3418253 | biostudies-literature
TranscriptomicsGender dependent differences in molecular electrophysiological targets in failing and nonfailing human hearts
Previous epidemiological studies have shown that males tend to have an increased overall lifetime risk of developing atrial fibrillation (AF), whereas females tend to be more susceptible to the development of ventricular tachyarrhythmias resulting from long-QT syndrome and drug-induced Torsades de P...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-33165 | biostudies-arrayexpress
TranscriptomicsPbx1-d Induces T cell Activation and a Decreased Apoptosis in Response to Retinoic Acids (RA)
The hypothesis was tested that the Pbx1-d isoform was responsible for the Sle1a.1 phenotypes in CD4+ T cells. Jurkat T cells were transfected with a lentiviral construct expressing Pbx1-d-GFP or control RFP. Pbx1-d over-expression reduced the percentage of late apoptotic cells in response to anti-C...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22799 | biostudies-arrayexpress
TranscriptomicsA TLR- and non-TLR-mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade
Lentiviral vector (LV)-mediated gene transfer is a promising method of gene therapy. We previously reported that systemic injection of LV triggers a transient inflammatory response. Here, we carried out studies to better characterize this response, and to develop a strategy to overcome the effects o...
ORGANISM(S): Mus musculus 
2013-07-05 | E-GEOD-39129 | biostudies-arrayexpress
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