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TranscriptomicsLXR activation in RAW264.7 mouse macrophages expressing LXRalpha.
To identify novel LXR target genes, we conducted transcriptional profiling studies using RAW264.7 cells ectopically expressing LXRalpha Total RNA was isolated from RAW264.7 macrophages ectopically expressing LXRalpha as described in Venkateswaran et al. (2000); PNAS 97, 12097-12102. Cells were cult...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-17088 | biostudies-arrayexpress
TranscriptomicsLiver X receptor beta is the dominant LXR subtype in skeletal muscle
Liver X receptors (LXRs) are important regulators of cholesterol, lipid and glucose metabolism and have been extensively studied in liver, macrophages and adipose tissue. However, their role in skeletal muscle is not yet fully elucidated and the functional role of each of the LXRM-NM-1 and LXRM-NM-2...
ORGANISM(S): Mus musculus 
2010-03-30 | E-GEOD-13192 | biostudies-arrayexpress
GenomicsGenome-wide profiling of LXR, RXR and PPARM-NM-1 in mouse liver reveals extensive sharing of binding sites
The liver X receptors (LXRs) are nuclear receptors that form permissive heterodimers with retinoid X receptor (RXR) and are important regulators of lipid metabolism in the liver. We have recently shown that RXR agonist-induced hypertriglyceridemia and hepatic steatosis in mice is dependent on LXR an...
ORGANISM(S): Mus musculus 
2012-01-31 | E-GEOD-35262 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptome in wild-type and LXR-deficient mice
LXR is a transcription factor. Two isoforms exist in mice (alpha and beta). They are both expressed in the liver. We examined the role of LXR by obtaining gene expression profiles from the livers of wild-type and LXR-/- mice from the same genetic background. Liver gene expression was measured from m...
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-38083 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse LXRalpha null, LXRbeta null mutants reveals liver X receptor beta is the dominant LXR subtype in skeletal muscle
Liver X receptors (LXRs) are important regulators of cholesterol, lipid and glucose metabolism and have been extensively studied in liver, macrophages and adipose tissue. However, their role in skeletal muscle is not yet fully elucidated and the functional role of each of the LXRalpha (NR1H3) and LX...
ORGANISM(S): Mus musculus 
2009-10-01 | E-MTAB-61 | biostudies-arrayexpress
GenomicsKlebsiella pneumoniae strain:LXR-1
Klebsiella pneumoniae strain:LXR-1 Genome sequencing
PRJNA820350 | ENA
GenomicsGenome-wide landscape of liver X receptor chromatin binding and gene regulation
Gene expression: Identification of primary target genes of liver X receptor (LXR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with LXR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by LXR. ChIP-Seq: We performed ChIP-seq in macro...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-28319 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers from Low Density Lipoprotein Receptor null mice expressing human LXR alpha to explore the molecular basis of metabolic effects of increased hepatic hLXR alpha.
Microarray analysis of liver RNA from male Low Density Lipoprotein Receptor null mice on C57B6 background expressing human LXR alpha or GFP (control) via adeno-associated virus (AAV2.8) gene transfer, under control of the liver specific human thyroxine binding globulin promoter. Samples are from 8 m...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2644 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary human CD4+ T cells treated with the LXR agonist GW3965, with and without TCR stimulation
We used RNA-sequencing to determine the transcriptional response to liver X receptor (LXR) activation in primary human CD4+ T cells, both at rest and under activation conditions. CD4+ T cells were isolated from 3 healthy donors and treated with the synthetic LXR agonist GW3965 (GW) for 24 hours. Gen...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-9141 | biostudies-arrayexpress
GenomicsLXR agonism enhances T cell activation upon crosspresentation by LXR-DKO BMDCs.
LXR agonism enhances T cell activation upon crosspresentation by LXR-DKO BMDCs.
PRJNA1050218 | ENA
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