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ProteomicsYBX3 is a versatile RNA-binding protein that controls amino acid import by regulating SLC mRNA abundance
Summary: Amino acids (AA) support protein synthesis, and thus cell growth and proliferation. Specialized transporters mediate AA exchange across membranes and their regulation is critical for AA homeostasis. Here, we report that the DNA- and RNA-binding protein YBX3 regulates the expression of AA t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-06 | MSV000083108 | MassIVE
TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clin...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer
To identify the potential ovarian cancer stem cell gene expression profile from isolated side population of fresh ascites obtained from women with high-grade advanced stage papillary serous ovarian adenocarcinoma Microarrays were used to interrogate the differentially expressed genes between side po...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-33874 | biostudies-arrayexpress
TranscriptomicsVariability of gene expression profiles in human blood and lymphoblastoid cell lines
Readily accessible samples such as peripheral blood or cell lines are increasingly being used in large cohorts to characterise gene expression differences between a patient group and healthy controls. However, cell and RNA isolation procedures and the variety of cell types that make up whole blood c...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30916 | biostudies-arrayexpress
TranscriptomicsA Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats
Introduction: Though heavy alcohol drinking has been well characterized as causing a variety of injuries, recent epidemiological evidence in humans suggests moderate consumption may provide beneficial effects. For example, there exists a J- or U-shaped relationship between the level of alcohol intak...
ORGANISM(S): Rattus norvegicus 
2013-05-07 | E-GEOD-46669 | biostudies-arrayexpress
TranscriptomicsOverexpression of Ssz1 S295F and Zuo1 amino acids 365-433 S427G in S. cerevisiae
WT strains were transformed with a control TAP plasmid, plasmid containing the Hsp70 chaperones Ssz1 containing a mutation in S295F, or J-domain containing protein Zuo1 amino acids 365-433 with the S427G mutation. These mutations are known to enhance the induction of the pleiotropic drug resistance ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-29 | E-GEOD-31693 | biostudies-arrayexpress
TranscriptomicsExpression data from control and Mbd4 KO CH12 cells that were activated with CIT for 24 hours.
AID-dependent U/G mismatches in S DNA are converted by BER and MMR DNA pathways into double-stranded breaks that are required for optimal CSR in activated B cells. Deficits in MMR proteins, MSH2, MLH1, and PMS2 result in lower CSR frequencies that are coupled with impaired DSB formation. MBD4 intera...
ORGANISM(S): Mus musculus 
2013-12-19 | E-GEOD-51559 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human Acute Lymphobastic Leukemia xenografts in mouse to validate the mouse model
Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms. For haematological malignancies, the non-obese diabetic/severe combined immunodeficient (NOD/SCID) mouse is one of the most successful models to ...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-MEXP-2648 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiles of peripheral monocytes and glioblastoma-infiltrating macrophages
MicroRNAs (miRNAs) are non-coding molecules involved in post-transcriptional gene regulation that have been shown to modulate tumor cell proliferation and apoptosis and to act as oncogenes or tumor-suppressor genes. Although miRNAs have been linked to tumor progression, the connection between tumor-...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-51332 | biostudies-arrayexpress
TranscriptomicsEvaluation of a New High-Dimensional miRNA Profiling Platform
We evaluated a new miRNA profiling platform that utilizes Illumina’s existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amoun...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17346 | biostudies-arrayexpress
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