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ProteomicsTumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
Development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-conditioning the brain ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015210 | Pride
Tumour exosomal cemi brain metastasis 
TranscriptomicsComparison of human embroynic stem cell derived vascular cells to mature human vascular and hematopoietic cells
The pathways involved in hierarchical differentiation of human embryonic stem cells (hESC) into abundant and durable endothelial cells (EC) are unknown. We employed an EC-specific VE-cadherin promoter driving GFP (hVPr-GFP) to screen for factors that augmented yields of vascular-committed ECs from h...
ORGANISM(S): Homo sapiens 
2010-01-05 | E-GEOD-19735 | biostudies-arrayexpress
ProteomicsTissue- and plasma-derived exosomal protein biomarkers define multiple human cancers
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of exosomes in 426 human samples from tissue explants (TE), plasma and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, HSP90AB1 represent ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-08-17 | PXD018301 | Pride
Exosomes  extracellular vesicles  proteomics  cancer  liquid biopsy  biomarkers  mass spectrometry  early cancer detection 
TranscriptomicsMassive sequencing of hybrid DNA obtained by DNA:RNA immunoprecipitation (DRIP) in extracellular microvesicles (MV) produced by HeLa cells (using S9.6 antibody)
Hybrid (Bound) and non-hybrid (Unbound) DNA from Hela EV was isolated using DRIP procedure as follows. Between 1-5μg of nucleic acid DNA from EVs (DNase0 treated) was incubated overnight with 1μg of anti-DNA-RNA Hybrid (S9.6) antibody (KeraFast) under rotation at 4°C in 500μl of binding buffer (10mM...
ORGANISM(S): Homo sapiens 
2023-03-30 | E-MTAB-9634 | biostudies-arrayexpress
UnknownBRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.
Not available
S-EPMC9622893 | biostudies-literature
TranscriptomicsId1 overexpressing BMDC
Trascriptional profiling by array of bone marrow derived murine cells trasduced with control and Id1-overexpressing vectors to identify genes changes induced by increased expression of the transcriptional regulator Id1
ORGANISM(S): Mus musculus 
2015-03-31 | E-MTAB-2280 | biostudies-arrayexpress
TranscriptomicsTumor exosome integrins determine organotropic metastasis
Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress
TranscriptomicsComparison of hepatic gene change after partial hepatectomy
Partial hepatectomy, resection of a portion of liver mass, indues significant liver regenerative responses that consist of numerous genetic changes. To identify specific genetic changes, we compare the liver of mice underwent either hepatectomy or sham operation. The experiment compared 2 sets of bi...
ORGANISM(S): Mus musculus 
2010-11-01 | E-GEOD-22879 | biostudies-arrayexpress
UnknownMulti-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer.
Not available
S-EPMC11416063 | biostudies-literature
UnknownPrehospital use of magnesium sulfate as neuroprotection in acute stroke.
Not available
S-EPMC4920545 | biostudies-literature
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