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UnknownStomach cancer risk after treatment for hodgkin lymphoma.
Not available
S-EPMC3770865 | biostudies-literature
UnknownHuman papillomavirus and rising oropharyngeal cancer incidence in the United States.
Not available
S-EPMC3221528 | biostudies-literature
ProteomicsContext-dependent and disease-specific diversity in stress granules formed from preexisting protein interactions
Affinity-capture proteomics studies using endogenously tagged G3BP1 with APEX2 to capture the stress granule proteome at steady state and upon stress induction. This was done in 293T cells as well as induced pluripotent stem cells differentiated into neuronal progenitor cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081554 | MassIVE
TranscriptomicsFunctional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency Implicating Wnt Signaling
Progranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN's function in the CNS remains largely unknown. To identify the pathways downstream of GRN, we used weighted genome co-expression network analysis (WGCNA) to develop a systems-level view of transcriptional alterations in a human...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31772 | biostudies-arrayexpress
TranscriptomicsAn Epigenetic Signature in Peripheral Blood Associated with Neurodegenerative Tauopathy and the Risk-Associated Haplotype on 17q21.31
Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) are two neurodegenerative diseases linked, at the pathologic and genetic level, to the macrutubule associated protein tau. We identified and replicated a dose-dependent effect of the risk-associated H1 haplotype on methylation le...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-53740 | biostudies-arrayexpress
TranscriptomicsProgranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Microglia repair injury and maintain homeostasis in the brain, but whether aberrant microglial activation can contribute to neurodegeneration remains unclear. Here, we use transcriptome profiling to demonstrate that deficiency in frontotemporal dementia (FTD) gene progranulin (Grn) leads to an age-d...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-75083 | biostudies-arrayexpress
UnknownDe novo design of pH-responsive self-assembling helical protein filaments.
Not available
S-EPMC11286511 | biostudies-literature
TranscriptomicsThe role of Gaq in MLL leukemogenesis
Beta-catenin has a central role for self-renewal of leukemic stem cells in Mixed Lineage Leukemia (MLL)-arranged acute myeloid leukemia (AML), however its upstream modulators that can enhance this pathway remain largely unexplored. Through genome-wide gene expression analysis, we identified a previo...
ORGANISM(S): Mus musculus 
2016-02-25 | E-MTAB-4078 | biostudies-arrayexpress
UnknownActionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Not available
S-EPMC7612986 | biostudies-literature
GenomicsWhole Genome Scan for Pancreatic Cancer Risk in the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium (PanScan)

Within the framework of the NCI-sponsored Cohort Consortium, investigators from 12 prospective epidemiologic cohorts formed the Pancreatic Cancer Cohort Consortium in 2006. This study, also known as "PanScan", is funded by the National Cancer Institute (NCI) and involves conducting a genome-w...

phs000206.v3.p2 | EGA
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