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TranscriptomicsFunctional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency Implicating Wnt Signaling
Progranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN's function in the CNS remains largely unknown. To identify the pathways downstream of GRN, we used weighted genome co-expression network analysis (WGCNA) to develop a systems-level view of transcriptional alterations in a human...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31772 | biostudies-arrayexpress
TranscriptomicsProgranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Microglia repair injury and maintain homeostasis in the brain, but whether aberrant microglial activation can contribute to neurodegeneration remains unclear. Here, we use transcriptome profiling to demonstrate that deficiency in frontotemporal dementia (FTD) gene progranulin (Grn) leads to an age-d...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-75083 | biostudies-arrayexpress
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