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ProteomicsEnhanced Characterization of Lysine-Linked Antibody Drug Conjugates Enabled by Middle-Down Mass Spectrometry
HCD Triggered UVPD and EThcD files for characterization of trastuzumab-emtansine (T-DM1)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-03 | MSV000092585 | MassIVE
ProteomicsSystem-Wide Identification of Wild-Type SUMO-2 Conjugation Sites
SUMOylation is a reversible post-translational modification regulating all nuclear processes. Identification of SUMOylation sites by mass spectrometry has been hampered by bulky tryptic fragments, which thus far necessitated the use of mutated SUMO. Here, we present a dataset generated through a SUM...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080714 | MassIVE
ProteomicsSite-Selective Protein Conjugation by a Multicomponent Ugi Reaction
The chemical bioconjugation of proteins has seen tremendous applications in the past decades, with the booming of antibody-drug conjugates and their use in oncology. While genetic engineering has permitted to produce bespoke proteins featuring key (un-)natural amino acid residues poised for site-sel...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD045387 | Pride
Biomolecule  site conjugation  chemical biology  peptide mapping 
ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080754 | MassIVE
UnknownCysteine-to-lysine transfer antibody fragment conjugation.
Not available
S-EPMC7066670 | biostudies-literature
ProteomicsIdentification of conjugation site of T-DM1
Ado-trastuzumab emtansine(T-DM1) is manufactured by conjugating DM1 to lysine of Trastuzumab via a non-cleavable linker in a non-specific mode.conjugated site of T-DM1 were identified using a bottom-up strategy through LC-HR-MS/MS.
ORGANISM(S): Homo sapiens environmental sample 
2025-03-05 | PXD054136 | Pride
Conjugation site Lc-ms/ms 
UnknownA noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins.
Not available
S-EPMC4314310 | biostudies-literature
UnknownAn accurate TMT-based approach to quantify and model lysine susceptibility to conjugation via N-hydroxysuccinimide esters in a monoclonal antibody.
Not available
S-EPMC6281681 | biostudies-literature
ProteomicsHaloferax volcanii lysine acetylation
Oxidative stress adaptation strategies are important to cell function and are linked to cardiac, neurodegenerative disease and cancer. Representatives of the domain Archaea are used as model organisms based on their extreme tolerance to oxidants and close evolutionary relationship with eukaryotes. S...
ORGANISM(S): Haloferax volcanii DS2 
2023-07-20 | PXD041799 | Pride
Ptms Halophiles Acetylation Haloferax volcanii Oxidative stress 
ProteomicsSecretory autophagy mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents an important mechanism in mitochondrial quality control (MQC) via clearance of damaged mitochondria. Although it is well known that the conjugation of mammalian ATG8s to phosphatidylethanolamine (PE) is a key step in autophag...
ORGANISM(S): Homo sapiens (Human) 
2022-06-03 | PXD025356 | Pride
Mitochondria Autophagy 
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