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MetabolomicsLysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

Lysosomes are key cellular organelles that metabolize extra- and intra-cellular substrates. Alterations in lysosomal metabolism are implicated in aging-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to ...

2022-05-06 | MTBLS4654 | MetaboLights
MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
ProteomicsKCMF1 links RAD6 to UBR4 and lysosome-mediated degradation
Raw mass spec. data files, converted peak lists and TPP results files for KCMF1 links RAD6 to UBR4 and lysosome-mediated degradation by Hong et. al, MCP 2014. RAD6 is a ubiquitin E2 protein with roles in a number of different biological processes. Here, using affinity purification coupled with mass ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-01 | MSV000078983 | MassIVE
GenomicsMitochondria-lysosome coupling contributes to lysosome acidification and aging
Mitochondria-lysosome coupling contributes to lysosome acidification and aging
PRJNA1240233 | ENA
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
ProteomicsProteomic analysis links truncated tau to lysosome motility, autophagy and endo-lysosomal dysfunction
Tauopathies are characterized by the progressive accumulation of abnormal tau species, which disrupt the autophagy-lysosomal pathway (ALP), a critical system for degrading intracellular macromolecules and aggregated proteins, causing toxicity and cell death. This study investigates the impact of the...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD062128 | Pride
Tauopathies Toxicity Proteomics Mass spectrometry Autosomal 
ProteomicsA quantitative proteomic profile revealed the crucial roles of lysosome in the microbial infection
Lysosome played vital roles for both innate and adaptive immunity. It has been widely accepted that lysosome functioned more than a digestive organelle. However, it was still largely unknown for the proteome changes of lysosome on various microbes, and the understanding of lysosomal proteome from th...
ORGANISM(S): Homo sapiens (Human) 
2017-05-04 | PXD005748 | Pride
Proteomics Hypoxia Lysosome Monocyte 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063036 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063031 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063029 | Pride
Lysosome Fgf Chordrocytes 
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