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MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
GenomicsOncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
ChIP-sequencing reads from Oncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication, accepted to PLOS Pathogens
ORGANISM(S): Homo sapiens 
2016-06-01 | E-MTAB-4356 | biostudies-arrayexpress
ProteomicsThe Kaposi’s sarcoma-associated herpesvirus ORF11 protein interacts with pre-ribosome complexes during lytic replication
Historically, ribosomes have been viewed as unchanged homogeneous macromolecular machines with no intrinsic regulatory capacity for mRNA translation. However, an emerging concept is that heterogeneity of ribosomal composition exists, which can exert a regulatory function or specificity in translatio...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-12-21 | PXD032367 | Pride
Microbiology/kaposi’s sarcoma-associated herpesvirus/specalised ribosomes/ribosome biogenesis 
ProteomicsA Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B-cells
Epstein Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B-cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication...
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD006317 | Pride
B-cell receptor Immune evasion Herpesvirus Complement Viral evasion Epstein-barr virus Lytic replication Host-pathogen interaction Quantitative proteomics Tandem mass tag 
ProteomicsTREx-BCBL1-RTA GPRC5A-FLAG Immunoprecipitation LC-MS
The epitranscriptomic modification m6A is a ubiquitous feature of the mammalian transcriptome. It modulates mRNA fate and dynamics to exert regulatory control over numerous cellular processes and disease pathways, including viral infection. Kaposi’s sarcoma-associated herpesvirus (KSHV) reactivation...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2023-07-20 | PXD039669 | Pride
Human kshv gprc5a 
TranscriptomicsEffect of endoplasmic reticulum stress on gene expression in lymphoblastoid cell lines.
The ER stress inducing agent Thapsigargin (TG) and/or the cytoprotective agent Salubrinal were applied to lymphoblastoid cell lines. TG induced lytic replication as well as a distinct pattern of gene expression changes. This study was designed to identify host genes mediating lytic replication secon...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-31447 | biostudies-arrayexpress
GenomicsBET proteins bind the lytic origins of replication [MutuI ChIP-seq]
BET proteins bind the lytic origins of replication [MutuI ChIP-seq]
PRJNA328409 | ENA
GenomicsBET inhibitors suppress lytic DNA replication [Akata-Zta DNA-seq]
BET inhibitors suppress lytic DNA replication [Akata-Zta DNA-seq]
PRJNA328410 | ENA
GenomicsOncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
Oncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
PRJEB12546 | ENA
GenomicsBET inhibitors suppress lytic DNA replication [Akata-Zta RNA-seq]
BET inhibitors suppress lytic DNA replication [Akata-Zta RNA-seq]
PRJNA328406 | ENA
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