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TranscriptomicsNew non-coding lytic transcripts derived from the Epstein Barr virus latency origin of replication oriP are hyper-edited, bind the paraspeckle protein, NONO/p54nrb, and support lytic viral transcription
We have previously shown that the Epstein-Barr virus (EBV) likely encodes hundreds of viral long non-coding RNAs (vlncRNAs) that are expressed during reactivation. Here we show that the EBV latency origin of replication (oriP) is transcribed bi-directionally during reactivation and that both leftwar...
ORGANISM(S): Human herpesvirus 4 
2015-05-21 | E-GEOD-68122 | biostudies-arrayexpress
ProteomicsTREx-BCBL1-RTA GPRC5A-FLAG Immunoprecipitation LC-MS
The epitranscriptomic modification m6A is a ubiquitous feature of the mammalian transcriptome. It modulates mRNA fate and dynamics to exert regulatory control over numerous cellular processes and disease pathways, including viral infection. Kaposi’s sarcoma-associated herpesvirus (KSHV) reactivation...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2023-07-20 | PXD039669 | Pride
Human kshv gprc5a 
ProteomicsKaposi’s sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs
Historically, ribosomes have been viewed as unchanged homogeneous macromolecular machines with no intrinsic regulatory capacity for mRNA translation. However, an emerging concept is that heterogeneity of ribosomal composition exists, which can exert a regulatory function or specificity in translatio...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-12-21 | PXD032318 | Pride
Microbiology/virology/herpes virus/human/specalised ribosome/ribosome biogenesis 
TranscriptomicsCapture-C identification of chromatin interactions of 53 selected cellular loci prior to and post induction of EBV's lytic cycle in Raji cells
Identification of specific chromatin interactions of 53 selected genes with the Capture-C technique in Raji iBZLF1 cells prior to and 6 or 15 h after induction of EBV’s lytic cycle. The experiments were performed as triplicates.
ORGANISM(S): Homo sapiens 
2019-04-05 | E-MTAB-7825 | biostudies-arrayexpress
ProteomicsThe Kaposi’s sarcoma-associated herpesvirus ORF11 protein interacts with pre-ribosome complexes during lytic replication
Historically, ribosomes have been viewed as unchanged homogeneous macromolecular machines with no intrinsic regulatory capacity for mRNA translation. However, an emerging concept is that heterogeneity of ribosomal composition exists, which can exert a regulatory function or specificity in translatio...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-12-21 | PXD032367 | Pride
Microbiology/kaposi’s sarcoma-associated herpesvirus/specalised ribosomes/ribosome biogenesis 
TranscriptomicsMock or KSHV cells (BJABJ, BCBL, TIME and HUVEC) vs common reference (mixture of RNA from both infected and uninfected cells)
Expression profiling of latently infected cells using a custom tiling microarray HUVEC and TIME cells were infected BCBL-1-derived KSHV. Mock infected HUVEC and TIME cells served as controls for each of these two stably infected cells, respectively. BJAB cells served as uninfected controls for the B...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-21972 | biostudies-arrayexpress
UnknownMultiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection.
Not available
S-EPMC5021424 | biostudies-literature
UnknownSimultaneous Detection of Herpes Simplex Virus Type 1 Latent and Lytic Transcripts in Brain Tissue.
Not available
S-EPMC9171132 | biostudies-literature
UnknownNew Noncoding Lytic Transcripts Derived from the Epstein-Barr Virus Latency Origin of Replication, oriP, Are Hyperedited, Bind the Paraspeckle Protein, NONO/p54nrb, and Support Viral Lytic Transcription.
Not available
S-EPMC4473578 | biostudies-literature
Unknownm6A Regulates the Stability of Cellular Transcripts Required for Efficient KSHV Lytic Replication.
Not available
S-EPMC10303434 | biostudies-literature
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